Flavonols are one of the largest groups of flavonoids that confer benefits for the health of plants and animals. Flavonol glycosides are the predominant flavonoids present in the model legume Lotus japonicus. The molecular mechanisms underlying the biosynthesis of flavonol glycosides as yet remain unknown in L. japonicus. In the present study, we identified a total of 188 UDP-glycosyltransferas...

We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli an...

The present study was undertaken to the effect of apigenin and luteolin on physiological histological changes in rats treated with cytarabine drugs. Thirty-five albino healthy male adult equal age weighing 250 -300g were enrolled. Rats randomly divided into seven groups according treatment. Group “1” normal saline served as control group. Groups “2,3 4” received cytarabine, apigenin, respective...

Astilbin (5,7,3',4'-tetrahydroxy-2,3-dihydroflavonol-3-ß-o-rhamnoside), a flavonoid with a large range of biological activities, was isolated from Dimorphandra mollis, a shrub common to the Brazilian Cerrado. The purpose of this study is to verify the effects of astilbin on myeloperoxidase (MPO) and horseradish peroxidase (HRP), and its antioxidant activity against hypochlorous acid (HOCl) and ...

T he m ajo r constituent of the yellow frond exudate of the fern Notholaena sulphurea was iden tified by spectroscopic m ethods as 3 ,5 ,2 '-trihydroxy-7-m ethoxy-8-acetoxy flavone and its struc tu re was confirm ed by synthesis. This novel natural flavonoid was also de tected in the frond exudate of five o ther Notholaena species. In the yellow form of N. sulphurea, the rare 5 ,2 'dihydroxy-7,...

The efficacy of dietary apigenin, a dietary flavonoid, in colon cancer prevention was investigated by evaluating the inhibition of the ornithine decarboxylase (ODC) activity and the formation of aberrant crypt foci (ACF) and by studying the ability of apigenin to block colon carcinogenesis in two mouse models. First, the activity of ODC was measured in colon cancer cells (Caco-2) and in the col...

Methanol 70% extract of Bauhinia racemosa aerial parts was tested for antimicrobial activity against different bacterial and fungal strains and for antioxidant activity and also total content of polyphenols with phytochemical analysis of the extract was determined. The results have showed that the extract has a significant antimicrobial activity, it inhibited the growth of Bacillus subtilis and...

Apigenin (4',5,7-trihydroxyflavone) is a member of the flavone subclass of flavonoids present in fruits and vegetables. The involvement of autophagy in the apigenin-induced apoptotic death of human breast cancer cells was investigated. Cell proliferation and viability were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and clonogenic assays. Flow cytometry, fluor...

A new flavonol glycoside derivate named kaempferol 3- O- trans- p-coumaroyl-7- α-ʟ-rhamnoside (1), together with five known compounds (2–6), was isolated from the EtOAc-soluble extract of leaves Tripterygium wilfordii. The structure compound elucidated spectroscopic and physico-chemical analyses. All isolates were evaluated for in vitro cytotoxic activity against four human cancer cells includi...