During neural tube closure, regulated changes at the level of individual cells are translated into large-scale morphogenetic movements to facilitate conversion of the flat neural plate into a closed tube. Throughout this process, the integrity of the neural epithelium is maintained via cell interactions through intercellular junctions, including apical tight junctions. Members of the claudin fa...

Changes in cell shape and position drive morphogenesis in epithelia and depend on the polarized nature of its constituent cells. The spectrin-based membrane skeleton is thought to be a key player in the establishment and/or maintenance of cell shape and polarity. We report that apical beta(Heavy)-spectrin (beta(H)), a terminal web protein that is also associated with the zonula adherens, is ess...

The objective of the research was to determine effectiveness obturation root canals and crown part teeth, identify most important factors influencing its results, based on X-ray examination.
 Materials methods: study conducted at Dental Center (University Clinic, Ivano-Frankivsk National Medical University). Evaluation 140 orthopantomograms, computed tomograms digital intraoral images pati...

Cadherin-based adherens junctions (AJs) mediate cell adhesion and regulate cell shape change. The nectin-afadin complex also localizes to AJs and links to the cytoskeleton. Mammalian afadin has been suggested to be essential for adhesion and polarity establishment, but its mechanism of action is unclear. In contrast, Drosophila melanogaster's afadin homologue Canoe (Cno) has suggested roles in ...

Electropalatographic data for several front lingual consonants, i.e., the dental /t/, the alveolars /n, l, s, r/ and the alveolopalatals /t∫, ∫, ʎ, ɲ/, show differences in constriction anteriority among Catalan dialects varying in the progression Valencian > Eastern, with the Majorcan dialect occupying an intermediate position. These differences do not conform to speaker- dependent differences ...

Non-muscle cell contractility is critical for tissues to adopt shape changes. Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. Here, combining the biochemical analysis of enzymatic and motile properties for purif...

Gastrulation of the Drosophila embryo is one of the most intensively studied morphogenetic processes in animal development [1-4]. Particular efforts have focused on the formation of the ventral furrow, whereby ∼1,000 presumptive mesoderm cells exhibit coordinated apical constrictions that mediate invagination [5, 6]. Apical constriction depends on a Rho GTPase signaling pathway (T48/Fog) that i...