BACKGROUND Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure. METHODS AND RESULTS Eighteen patients with New York Hear...

Objective(s): Considering the lack of information, the effects of mild endurance exercise plus blood flow restriction (BFR) on electrocardiographic parameters, hypertrophy index, and expression of angiotensin II receptors type 1 (AT1R) and type 2 (AT2R) and apelin receptor (APJ) were assessed in hearts of old male rats.Materials and Methods: Animal were grouped as control (CTL), Sham (Sh), lowe...

A key step in the de novo formation of the embryonic vasculature is the migration of endothelial precursors, the angioblasts, to the position of the future vessels. To form the first axial vessels, angioblasts migrate towards the midline and coalesce underneath the notochord. Vascular endothelial growth factor has been proposed to serve as a chemoattractant for the angioblasts and to regulate t...

The G protein-coupled receptor (GPCR) dimer interface plays an important role in the formation and stabilization of dimer. Therefore, identifying potential receptor-receptor is part studying GPCRs. Various strategies have been employed to study GPCR explore its functional significance, but experimental methods lack robustness calculations are laborious. Herein, we report a combined optimized ca...

Apelin peptides mediate beneficial effects on the cardiovascular system and are being targeted as potential new drugs. However, apelin peptides have extremely short biological half-lives, and improved understanding of apelin peptide metabolism may lead to the discovery of biologically stable analogues with therapeutic potential. We examined the ability of angiotensin-converting enzyme 2 (ACE2) ...

Background—Apelin, the endogenous ligand for the novel G protein– coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure. Methods and Results—Eighteen patients with New York Heart...

Heart failure is the leading cause of death in diabetic patients. Recently we showed that apelin gene therapy attenuates heart failure following myocardial infarction. This study further explored the potential mechanisms by which apelin may reduce cardiac injury in Postmyocardial infarction (MI)) model of diabetes. Wild type and Sirt3 knockout (Sirt3 KO) mice were induced into diabetes by intra...

Interactions between astrocytes and endothelial cells (ECs) are crucial for retinal vascular formation. Astrocytes induce migration and proliferation of ECs via their production of vascular endothelial growth factor (VEGF) and, conversely, ECs induce maturation of astrocytes possibly by the secretion of leukemia inhibitory factor (LIF). Together with the maturation of astrocytes, this finalizes...

OVER THE PAST 30 YEARS, THERE has been considerable interest in the elucidation of factors that mediate angiogenesis. These efforts led to the identification of factors such as vascular endothelial growth factor (VEGF), acidic and basic fibroblast growth factor (FGF-1 and -2), and angiopoietins, to name a few. Subsequent detailed investigations have revealed that finely tuned and precisely coor...

conclusions it appears that fenugreek seed might be effective against hyperglycemia, hyperlipidemia and insulin resistance in ovariectomized rats without impact on serum apelin. furthermore, 17-β estradiol could have similar effects along with possible inhibitory effects on serum apelin. the complicated role of apelin in menopause needs to be further explored. results serum apelin, glucose, lip...