The aim of the present work was to verify the in vivo capacity of pantoprazole-loaded microparticles to protect the gastric mucosa against ulcer formation and to evaluate their stability under accelerated conditions. Pantoprazoleloaded microparticles were prepared by spray-drying in pilot scale, using Eudragit ® S100 as polymer. Transparent glass vials containing drug-loaded microparticles were...

Interaction of the antipsychotic drug risperidone with hydroxypropyl-beta-cyclodextrin (HPBCD) in solution and in the solid state was studied with the aim of overcoming the limitations associated with nasal administration of low solubility drugs. Risperidone solubility studies revealed inclusion complex formation with a 1:1 stoichiometry. Low concentrations (0.1 w/v %) of hydroxypropylmethyl ce...

Objectives: The partly modifiable risk factors, that constitute the metabolic syndrome (MetS), do not fully account for the associated functional and structural vascular abnormalities and increased cardiovascular disease risk. Cell-derived microparticles, which reflect ongoing cellular stress but also associate with cardiovascular disease, are elevated in subjects with MetS in the fasting state...

Microparticles, which were initially described as cell dust, have revealed over the past few years several exciting and unexpected properties. Microparticles are submicron vesicles shed from plasma membranes following cell activation or apoptosis, whose protein and lipid profile may be considered as a snapshot of the phenotype of the cell they stem from. The molecular mechanisms of microparticl...

Novel microparticles based on chitosan and sodium alginate were prepared using emulsification and cross-linking technologies. The spherical microparticles had a porous surface and a diameter of 2 ~ 40 μm. In simulated body fluid, these microparticles quickly swelled but gradually degraded. The results of the MTT assay revealed that a slight inhibition of cell proliferation was observed on day 2...

Inflammation in the setting of interstitial lung disease (ILD) occurs in the distal alveolar spaces of the lung, which presents significant challenges for therapeutic delivery. The development of aerosolizable microparticles from non-immunogenic polymers is needed to enable the clinical translation of numerous experimental therapeutics that require localization to the deep lung and repeated del...

Microparticles are membrane vesicles with pro-inflammatory properties. Circulating levels of microparticles have previously been found to be elevated in patients with metabolic syndrome (MetS). The present study aimed to evaluate the effects of in vivo treatment with microparticles, from patients with MetS and from healthy subjects (HS), on ex vivo vascular function in mice. Microparticles isol...

Laboratory scale studies have repeatedly reported high P-retention in slag, a by-product of the steel manufacturing industry. Thus, it has emerged as a potential material to increase P-removal from constructed wetlands (CWs). However, several limitations were highlighted by field experiments, including the high pH of treated water and clogging. We hypothesized that the addition of sedimentary r...

a Cemagref, research unit: Water quality and pollution prevention, 3 bis, quai Chauveau-CP 220, 69336 Lyon Cedex 9France (E-mail: [email protected]; [email protected]; [email protected]) b IRCE Lyon, CNRS-UMR 5256, université Claude Bernard Lyon 1-domaine scientifique de la Doua-VilleurbanneFrance (E-mail: [email protected]) c SINT, 5 rue Boyd, F7...

INTRODUCTION: Strontium plays important role in stimulating the growth of osteoblasts and enhancing the formation of new bone. Therefore, a strontium related compound strontium ranelate (SR) has recently been suggested for use as a daily supplement to treat osteoporosis. However, the true effect of strontium to the stability of hydroxyapatite (HAp) has not been well understood yet, such as why ...