BACKGROUND Symptomatic paroxysmal hypertension without significantly elevated catecholamine concentrations and with no evidence of an underlying adrenal tumor is known as pseudopheochromocytoma. METHODS We describe the case of a female patient with paroxysmal hypertensive crises accompanied by headache, vertigo, tachycardia, nausea and altered mental status. Previously, she was treated for a ...

BACKGROUND The prevalence of multimorbidity is increasing worldwide, presumably leading to an increased use of medicines. During the last decades the use of hypnotic and anxiolytic benzodiazepine derivatives and related drugs has increased dramatically. These drugs are frequently prescribed for people with a sleep disorder often merely designated as "insomnia" in the medical records and lacking...

cannabinoids induce diverse responses on anxiolytic–like behaviors. moreover some studies postulated that there is a close relationship between this system and serotonergic system upon cognitive process formation. thus the aim of present study is investigation the possible role of 5-ht 1 receptor on anxiolytic–like behaviors induced by acpa in the elevated plus maze task (epm). in the present s...

Turnera aphrodisiacaWard (Turneraceae) has been traditionally used for the treatment of anxiety neurosis and as aphrodisiac, but no attempts have been made to investigate the plant systematically for its traditional claims. The current investigation was carried out ot isolate the bioactive constituent(s) from T. aphrodisiaca using bioactivity-guided fractionation. Antianxiety activityguided fra...

The primary use of sedative–hypnotic and anxiolytic drugs is to encourage calmness (anxiolytics or sedatives) or to produce sleep (sedative–hypnotics). All people are subject to states of emotional tension and uneasiness. For otherwise healthy individuals, these occasions are usually sufficiently mild and short that pharmacological intervention is unnecessary. However, at times the symptoms of ...

One of the main components of the stress system is hypothalamus- pituitary-adrenal (HPA) axis. Acute activation of µ-opioid receptors increases the activity of the HPA axis, leading to release of ACTH and corticosterone. Glucocorticoids can change behaviors, depend on age but there were no evidences about the interaction between age, opioid system and glucocorticoids. In this experiment, ...

Introduction: Previous studies have shown that the cannabinoid system is involved in anxiety.In addition, transient receptor potential vanilloid type-1 (TRPV1) channels are new targets for the development of anxiolytics. The present study investigated the possible interaction between the cannabinoid and vanilloid systems on anxiety-like behavior in rats. Methods: Four different groups of male ...

we studied the effect of the selective alha-2 adrenoceptor blocker idazoxan and precursor serotonin (5-htp) on anxiety-related behavior in rats. the conflict drinking test, and evaluator plus-maze were used as model. idazoxan (2 mg/kg) showed an anticonflict effect, having doses dependently increased the number of punished lickes. 5-htp showed that anxiolytic-like effect in both models. this dr...