The prevalence of chronic viral infectious diseases, the emergence and re-emergence of new viral infections, and in particular, resistance to currently used antiviral drugs have led to increased demand for new antiviral strategies and reagents. Increased understanding of the molecular mechanisms of viral infection has provided great potential for the discovery of new antiviral agents that targe...

BACKGROUND Wide-scale use of antiviral agents in the event of an influenza pandemic is likely to promote the emergence of drug resistance, with potentially deleterious effects for outbreak control. We explored factors promoting resistance within a dynamic infection model, and considered ways in which one or two drugs might be distributed to delay the spread of resistant strains or mitigate thei...

As the development of any drug and that too antiviral always requires time, in this Corona virus pandemic no specific drugs have been approved for coronavirus disease 2019 (COVID-19) till date. Therefore, assessment, analysis use currently available become a challenge medical field timely response to current pandemic. Here, we tried review anti CoV-2 potencies reverse transcriptase drugs. Sever...

This review highlights a wide range of research on antiviral natural products in Asia in the period from 2000 to 2008. It focuses on the most important findings in this field specifically on the plants' components with potential antiviral activity against wide range of pathogenic DNA and RNA viruses. In addition, the difference between Asians and other populations regarding their habits of usin...

At the beginning of 2020, Covid-19 epidemic broke out and soon became a global public health problem. Therefore, many countries are speeding up development antiviral drugs COVID-19 vaccines to achieve effective prevention, control, treatment Covid-19. This paper reviews pathogenic mechanism detection diagnosis status research progress drugs, vaccines, some other treatments against it based on p...

BACKGROUND Endoretroviruses account for circa 8 % of all transposable elements found in the genome of humans and other animals. They represent a genetic footprint of ancestral germ-cell infections of exoviruses that is transmittable to the progeny by Mendelian segregation. Traces of human endogenous retroviruses are physiologically expressed in ovarial, testicular and placental tissues as well ...

Soon after the first novel influenza A (H1N1) death was documented in Korea on August 15, 2009, prompt treatment with antiviral drugs was recommended when an infection was suspected. Free antiviral drugs were distributed to patients who met the case definition in the treatment guidelines, and patients prescribed the antiviral drugs were included in the Antiviral Drug Surveillance System (ADSS)....

OBJECTIVE Mutations associated with HIV drug resistance have been extensively characterized at the HIV-1 polymerase domain, but more studies have verified that mutations outside of the polymerase domain also results in resistance to antiviral drugs. In this study, mutations were identified in 354 patients experiencing antiretroviral therapy (ART) failure and in 97 naïve-therapy patients. Mutati...

BACKGROUND A small number of individuals with B-cell-related primary immunodeficiency diseases (PIDs) may exhibit long-term (prolonged or chronic) excretion of immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) following infection with oral poliovirus vaccine (OPV). These individuals pose a risk of live poliovirus reintroduction into the population after global wild poliovirus er...

Benzomorphan core is a versatile structure. In fact, it represented the skeleton of drugs with different mechanism of action, from opioid to σ1 receptor, from antiviral to antiproliferative. Based upon these considerations, the design, synthesis and biological evaluation of benzomorphan-based compounds as putative antiviral and/or antitumoral drug candidates could represent a valid and versatil...