DAA: direct antiviral agents HCV: hepatitis C virus LP: lichen planus INTRODUCTION Lichen planus (LP) is a chronic inflammatory disease affecting the skin and mucosa of squamous cell origin and has a significantly higher prevalence in patients infected with the hepatitis C virus (HCV). Although ribavirin-based treatments frequently show exacerbations of these lesions, currently there is little ...

Citation: Quintela BM, Conway JM, Hyman JM, Guedj J, dos Santos RW, Lobosco M and Perelson AS (2018) A New Age-Structured Multiscale Model of the Hepatitis C Virus Life-Cycle During Infection and Therapy With Direct-Acting Antiviral Agents. Front. Microbiol. 9:601. doi: 10.3389/fmicb.2018.00601 A New Age-Structured Multiscale Model of the Hepatitis C Virus Life-Cycle During Infection and Therap...

BTD, Ltd. has introduced a new direction in the use of antisense agents in therapeutics that can lead to breakthroughs in the development of antiviral drugs. As described in this non confidential summary, it has already resulted in the development of promising antiviral agents, as demonstrated by their significant in vitro and in vivo effects on hepatitis C virus activity as well as on other vi...

AbstractPyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensi...

The current study involves the synthesis of fourteen analogs oligochitosan and their screening for antiviral potential against human immunodeficiency virus (HIV), respiratory syncytial (RSV) Coxsackie virus. synthesized were characterized by nuclear magnetic resonance (NMR) FTIR techniques. HIV-1 p24 ELISA was performed using antigen capture assay in order to estimate viral infectivity loss. It...