نتایج جستجو برای: antitumor bioactivity
تعداد نتایج: 44680 فیلتر نتایج به سال:
Nowadays, titanium-based alloys are among the most attractive metallic materials for biomedical applications (as implants) due to their non-biodegradability, low density, good mechanical properties as well as their good biocompatibility. Hydroxyapatite (Ca10 (PO4)6(OH)2, HA) has been widely used for biomedical applications due to its bioactive, biocompatible and osteoconductive properties. Firs...
In this study, NBG was successfully achieved through a sol-gel technique, and to further improve its dispersibility, a crylate coupling agent was coupled onto the surface of the NBG. The 3-(Trimethoxysilyl)Propylmethacrylate coupling agent was used to the surface modification of the synthesized NBG by a wet-chemical method in a dynamic inert nitrogen atmosphere. The surface properties of the bi...
Expression of eukaryotic proteins in E. coli often results in their aggregation. Proper folding and solubility of therapeutical proteins are the pre-requisite for their bioactivity. This is not achieved in cytoplasmic expression in E. coli because of the absence of disulfide bonds formation. A novel expression/secretion vector was constructed which exploited β-lactamase signal sequence to trans...
ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 and 2014 Nucleic Acids Research Database Issues. Since then, alongside the continued extraction of data from the medicinal chemistry literature, new sources of bioactivity data have also been added to the database. These include: deposited data sets from neglected disease screenin...
Effects of alloying element Ca on the corrosion behavior and bioactivity of films formed by plasma electrolytic oxidation (PEO) on AM60 alloys were investigated. The corrosion behavior was studied by conducting electrochemical tests in 0.9% NaCl solution while the bioactivity was evaluated by soaking the specimens in simulated body fluid (SBF). Under identical anodization conditions, the PEO fi...
Recombinant human erythropoietin (rHuEPO) variants have been constructed to identify amino acid residues important for biological activity. Immunoassays were used to determine the effect of each mutation on rHuEPO folding. With this strategy, we could distinguish between mutations that affected bioactivity directly and those that affected bioactivity because the mutation altered rHuEPO conforma...
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