Due to its beneficial natural and pharmacological properties, heterocyclic element analogues derivatives have recently received a lot of attention. One the frequently occurring nuclei in both marine grow solutions is benzothiazole. A favoured bicyclist band method with numerous utilizations It well known for exhibiting broad variety activities, including those that are anticancer, antiviral, an...

Hydrazones are a special class of organic compounds in the Schiff base family. Hydrazones constitute a versatile compound of organic class having basic structure (R1R2C=NNR3R4). The active centers of hydrazone, that is, carbon and nitrogen, are mainly responsible for the physical and chemical properties of the hydrazones and, due to the reactivity toward electrophiles and nucleophiles, hydrazon...

There has been considerable interest in various analogues of antitubercular drugs particularly against multidrug and extensively drug resistant tuberculosis because mycobacterium species has developed resistant against available drugs. The currently used antitubercular also causes some serious toxic effects and also require long period of therapy for the treatment. Therefore, various new drugs ...

A 24-year old female was admitted with multiple discharging sternal sinuses involving the whole sternum. The cultures grew Mycobacterium tuberculosis. The chest computed tomography (CT) (Figs. 1 and 2) showed the complete destruction of the sternum and paraspinal collection. Triple antituberculosis treatment, surgical drainage of the sternal and spinal abscess and adequate nutrition resulted in...

Background: Despite availability of antituberculosis treatment and application of directly observed treatment short-course (DOTS) strategy, loss to follow-up in tuberculosis (TB) treatment is still a problem in controlling TB, especially in TB high-burden countries. Methods: This retrospective survey study to determine the magnitude and factors influencing loss to follow-up TB treatment was con...

Endobronchial tuberculosis (EBTB) and chylothorax are rare clinical disorders. The concurrence of these two disorders as manifestations of childhood pulmonary tuberculosis has not been reported. We report a 4-month-old boy presenting with chylothorax as the initial presentation of tuberculosis that has been successfully treated with octreotide, antituberculosis drugs and steroid therapy.

We have developed a Real-Time PCR assay to detect M. tuberculosis using the iCycler iQ detection system by TaqMan assay directly on the clinical specimen. A total of 513 clinical samples were taken from patients with suspected tuberculosis and other patients that had an active mycobacterial infection, as well as patients with diagnosed tuberculosis who were receiving antitubercular therapy. The...

The mutant prevention concentration (MPC) of a C-8-methoxy fluoroquinolone exhibited a narrow distribution for 14 genetically diverse clinical isolates of Mycobacterium tuberculosis, indicating that results from single-isolate studies are likely to be representative. When one isolate was challenged with a variety of antituberculosis agents, C-8-methoxy fluoroquinolones were exceptional in havin...

r The 1938 report of the work m (Anti-Tuberculosis) Fund on by that bo Jsig *as the last report to be ^ ror's Anti-Tube ciation Fund was along with King-E P ^erculosns A Fund incorporated into the^u?|39. The settmg^.^ ?f India on the 23rd Februa y^e tuberculosis n of the central and province pl, ncy's ??=+ tubertions as a result of Her Exf hency^ against tu^ a renewed life to the whole ^ vcry i...