Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that undergoes extensive phase I and II metabolism. To better understand the kinetics of this process and to characterize the dynamic changes in metabolism and pharmacokinetics (PK) between children and adults, we developed a physiologically based PK (PBPK) model for APAP integrating in silico, in vitro, and in vivo PK data in...

Acetylsalicylic acid is widely used in human medicine. The dose depends on the condition to be treated: the therapeutic dose for anti-inflammatory, antipyretic and analgesic indications is 300 to 900 mg/person every 4 to 6 hours, with a maximum of 4000 mg/person/day. Several long-term (sometimes life-long) low dose regimes beginning at doses of 50 mg/person are also used for several cardiovascu...

The acetone extracts of Radix paeoniae (Paeonaceae) root (100 and 200 mg/kg orally) were tested in brewer's yeast-induced pyrexia in rats to assess their antipyretic activity. The pyrexia in rats was reduced significantly (P < 0.05) compared to that of control. These results indicate that the extracts possess antipyretic properties. The root extract showed significant reduction in normal body t...

BACKGROUND In childcare centres, temporary exclusion of ill children, if their illness poses a risk of spread of harmful diseases to others, is a central approach to fight disease transmission. However, not all ill children need to be excluded. Previous studies suggested that childcare centre staff have difficulties in deciding whether or not to exclude an ill child, even when official ill-chil...

The article presents the results of analysis clinical features gastroenterological manifestations a new coronavirus infection (COVID-19) caused by pathogen SARS-CoV-2. Taking into account stage-by-stage system assessment experience treating 1,180 patients in multi-specialty hospital transformed an infectious hospital, most characteristic digestive damage SARS-CoV-2 are described. focuses on ver...

Scrub typhus is transmitted by the bite of chiggers (larvae) Leptotrombidium deliense and caused bacteria Orientia tsutsugamushi. Common symptoms include fever, headache, lymphadenopathy, black eschar formation, while acute pancreatitis a rare complication. We present case 27-year-old gentleman, who presented with epigastric pain constipation for three weeks, fever four days, vomiting two days....

INTRODUCTION The aim of this article is to determine the most common substances involved in unintentional poisoning in children attending Pediatric Emergency Departments (PED) in Spain. METHODS A descriptive study was conducted based on a prospective registry of the poisonings registered in the 57 PED participating in the Toxicology Surveillance System of the Spanish Society of Pediatric Emer...

Fever is the most common complaint among children brought into the emergency department (ED). 'Fever phobia' is a descriptive term for an unrealistic concern about the consequences of fever. 'Fever phobia' is prevalent among parents and even healthcare providers, worldwide. The aim of this study was to determine the implications of fever-phobic ideas in Korean caregivers. A prospective, multi-c...