Eleucine indica is a medicinal plant used by the Ibibios of southern Nigeria in the treatment of malaria fever and also as a tonic. This study was to evaluate the antipyretic activities of the ethanol extract and the antioxidant activities of the extract, n-hexane, chloroform, ethyl acetate, butanol and aqueous fractions of the whole plant. Basal rectal temperatures of adult albino rats of both...

The importance of pyrimidine nucleus in the metabolism of neurone is well recognised. Several compounds which are intimately concerned wrth the essential life processes of the neurones such as vitamins, coenzymes and both RNA and DNA of the mitochondria and of the nuclei contain pyrimidine moiety. It is not surprising that quite a large number of central nervous system depressants are derived f...

Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana. Xylopic acid, a pure compound isolated from the fruits of the Xylopia aethiopica, was investigated to establish its attributable prophylactic, curative antimalarial, and antipyretic properties. The anti...

The present study was aimed at evaluation of the anti-inflammatory, analgesic and antipyretic activities of petroleum ether and ethanolic extract of aerial parts of Mollugo pentaphylla Linn. In experimental standard models. The results showed that the ethanolic extract significantly reduce the edema induced by carrageenan within 1 to 3 hrs. post dosing and Cotton-pellet induced granuloma models...

Aspirin (acetylsalicylic acid), with fewer adverse reactions than salicylic acid, was first generated as an antipyretic analgesic through acetylation of salicylic acid in the late 19th century [1-3]. Since then, aspirin has long been used as an ingredient in anti-inflammatory agents worldwide and is commonly used as a drug with antiinflammatory, antipyretic and analgesic effects, as well as ant...

Ziziphus nummularia from Rhamnaceae family is traditionally used for sedative-hypnotic, antipyretic and analgesic purposes; however, scientific validations are lacking. This in vivo study was undertaken to verify the above ameliorative properties of Z. nummularia root methanolic extract. Various fractions of the extract were assayed on Balb/c mice by open field, Brewer's yeast-induced hyperther...

The thiazolidin-4-one derivatives and the corresponding spiro compounds were synthesized from sulphanilamide and were evaluated for anti-inflammatory and analgesic activity in acute and sub acute models. Compounds were also evaluated for antipyretic and cyclooxygenase enzyme inhibitory activity. All the compounds showed significant antiinflammatory, analgesic and antipyretic activity at 100 mg/...

Schiff bases and phenyl hydrazone of isatins were prepared by reacting isatin and the appropriate aromatic primary amine/hydrazines. A new series of the corresponding N-mannich bases were synthesized by reacting them with formaldehyde and diphenylamine. The chemical structures were confirmed by means of their 1H-NMR, IR spectral data and elemental analysis. The compounds were screened for analg...

Putranjiva roxburghii Wall. is a well-known plant which has been ascribed an important role in Ayurvedic texts as an antipyretic, anti-inflammatory & anti-rheumatic herb useful in gynaecological and fertility ailments. The pharmacognosy of its leaves, fruits, root and stem bark indicates the presence of many glycosides, saponins, triterpenes and flavonoids. Its leaf extract has been found suita...

Wattakaka volubilis (Family: Asclepiadaceae) has been reported to possess medicinal effects. In the present study, the dried root ethanol extract of W. volubilis designated as 'the extract' was evaluated for pharmacological activity in rats and mice. The anti-inflammatory and antipyretic activities were evaluated in rodents. The analgesic activity was evaluated in mice models. In the acute toxi...