From well-known antioxidants agents, we developed a first pharmacophore model containing four common chemical features: one aromatic ring and three hydrogen bond acceptors. This model served as a template in virtual screening of Maybridge and NCI databases that resulted in selection of sixteen compounds. The selected compounds showed a good antioxidant activity measured by three chemical tests:...

Lycopene nanoemulsions were prepared to protect the antioxidant activity and improve the bioaccessibility of lycopene-enriched tomato extract (containing 6% of lycopene) by an emulsification-evaporation method. Lycopene nanoemulsions, with droplet sizes between 100 and 200 nm, exhibited higher anti-radical efficiency and antioxidant activity, than did those smaller than 100 nm. Strong protectab...

This study focuses on the effect of extrusion processing on tannin reduction, phenolic content, flavonoid content, antioxidant and anitimicrobial activity. Extrusion temperature (120 and 140 °C) and feed moisture (25% and 28%) were used on the tannin content, antioxidant and antimicrobial activities. Extrusion cooking reduced tannin content up to 78%, and improved antioxidant activity from 12.8...

Background. Antioxidants are defined as compounds that able to delay, slow down, or inhibit oxidation reactions. One of the plants has potential natural antioxidants is telang flower. The purpose this study was determine whether ethanol extract flower (Clitoria ternatea L.) can be formulated in a losion form meets requirements physical evaluation test and antioxidant activity. Methods. extracti...

Antioxidants are compounds that prevent or delay the oxidation process, acting at a much smaller concentration, in comparison to of preserved substrate. Primary antioxidants act as scavenging chain breaking antioxidants, delaying initiation interrupting propagation step. Secondary quench singlet oxygen, decompose peroxides non-radical species, chelate prooxidative metal ions, inhibit oxidative ...

enhancement of antioxidant capacity of plants by natural antioxidants obtained from medicinal plants can be a simple way to produce stress tolerant plants. zataria multiflora essential oil (zo) is one of the useful antioxidants with potent antioxidant activity. zo is insoluble in water and can be degraded by light, oxygen, and high temperature. incorporation of zo into poly vinyl alcohol (pva) ...

Molyneux, P. The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity Songklanakarin J. Sci. Technol., 2004, 26(2) : 211-219 The use of the stable free radical diphenylpicrylhydrazyl (DPPH) to estimate the activity of antioxidants is reviewed. Current applications of the method are examined, particularly the use of the parameter EC50 (substrate concen...

Ethanol extract of Passiflora edulis Sims was analyzed for its antioxidant (1,1-diphenyl-2-picryl hydrazyl radical reducing power methods) and phytochemical analysis. The extract was found effective against the antioxidant test models exhibiting an IC(50) value of 875+/-87.83 mug/ml and showed strong potential antioxidant activity in both assays.

Oxidative stress originates from an elevated intracellular level of free oxygen radicals that cause lipid peroxidation, protein denaturation, DNA hydroxylation, and apoptosis, ultimately impairing cell viability. Antioxidants scavenge reduce oxidative stress, which further helps to prevent cellular damage. Medicinal plants, fruits, spices are the primary sources antioxidants time immemorial. In...