This study's purpose was to determine if a correlation exists between cochlear antioxidant activity changes and auditory function after induction of amino-glycoside (AG) ototoxicity. Two groups of five 250-350 g albino guinea pigs served as subjects. For 28 days, albino guinea pigs were administered either 200 mg/kg/day amikacin, or saline subcutaneously. Auditory brainstem response testing was...

Korean raspberry, Rubus coreanus Miquel (RCM), contains high concentrations of phenolic compounds, which prevent oxidative stress. To determine the effect of RCM on antioxidant capacity in humans, we assessed in vivo lipid oxidation and antioxidant enzyme activities from plasma in 15 healthy men. The subjects ingested 30 g of freeze-dried RCM daily for 4 weeks. Blood was taken at baseline and a...

The objective of the study was to evaluate oxidative stress (OS) status in subjects with different cardiovascular risk factors. With this in mind, we have studied three models of high cardiovascular risk: hypertension (HT) with and without metabolic syndrome, familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH) with and without insulin resistance. Oxidative stress marke...

abstract effect of different concentrations of salicylic acid on postharvest life of kiwifruit (actinidia deliciosa) cultivar hayward at 0 ±.5 °c and 90-95% rh was studied. fruits were treated with salicylic acid (0, 1 and 2 mmol/l-1) and stored at 0±.5°c for 16 weeks. fruit quality attributes assessment including firmness, total acidity, soluble solid content, ascorbic acid, antioxidant activi...

three different experiments were conducted to study the effect of dietary astaxanthin on the immune response, resistance to white spot syndrome virus (wssv) and transcription of antioxidant enzyme genes in pacific white shrimp litopenaeus vannamei. each experiment included one triplicate treatment group (fed with 80 mg/kg astaxanthin supplemented diet) and one triplicate control group (fed with...

AIM Excess levels of free radicals such as nitric oxide (NO) and superoxide anion (O(2)(-)) are associated with the pathogenesis of endothelial cell dysfunction in diabetes mellitus. This study was designed to investigate the underlying causes of oxidative stress in coronary microvascular endothelial cells (CMECs) exposed to hyperglycaemia. METHODS CMECs were cultured under normal (5.5 mmol/l...

zagros (drought tolerant) and pishtaz (drought susceptible) cultivars were classified on the basis of shoot dry weight and were used as plant material in this study. total chlorophyll, carotenoids, antocyanins, proline, soluble sugar contents, lipid peroxidation, antioxidant enzyme activities and protein patterns were determined. seedlings of wheat genotypes were grown in nutrient solution cult...

Apolipoprotein E (APOE) and oxidative damage were correlated with the risk of Alzheimer's disease (AD). Glutathione S-transferase (GST) polymorphism was proved to be associated with body antioxidant capacity and involved in the oxidative damage related chronic diseases. To explore the combined effects of APOE rs429358, rs7412 and GSTM1/T1 polymorphism on antioxidant parameters and cognition in ...