Lilium candidum L. (Liliaceae), the so called “white Madonna lily”, is well known in folk medicine for the treatment of burns, ulcers, inflammations and for healing wounds. Lilium candidum L. extract contains various biologically active compounds. As the antimutagenic activity of natural compounds often correlates with antioxidant effects and contents of phytochemical substances from the flavon...

INTRODUCTION Observations of mice, rats, and human clinical trials demonstrate the efficacy of low-dose radiation immunotherapy. The immune system is an essential component of effective antimutagenic control of the enormous burden of relentless metabolic DNA alterations produced by reactive oxygen species (ROS) leaked from mitochondria. Our modeling of the human antimutagenic biosystem includes...

The discovery of anticancer agents paradigm has been shifted to natural resources to overcome the toxicity of many synthetic agents at early clinical stages. In the present study, the antimutagenic, anticancer, phytochemistry, and free radical scavenging activities of five extracts of Conyza triloba were investigated. Extracts II (water : methanol), III (methylene chloride), and IV (methylene c...

4478 Antimutagenic Effects of 2(3)-tert-Butyl-4-hydroxy anisole and of Antimicrobial Agents. tivities and Protection against Mutagenic Metabo lites of Benzo(a)pyrene by Dietary Antioxidants.

The use of medicinal plants dates back to the beginning of humanity, and today their application as complementary therapy has been widely disseminated as an alternative to conventional therapy. The medicinal plant named Uncaria tomentosa (Willd.) DC. (known as cat's claw) is a common woody vine of the Amazon forest that has traditionally been used in the treatment of arthritis because of its an...

It is estimated that 60% of anticancer drugs are derived directly or indirectly from medicinal plants. Schinus terebinthifolius Raddi (Anacardiaceae) is traditionally used in Brazilian medicine to treat inflammation, ulcers, and tumors. Because of the need to identify new antimutagenic agents and to determine their mechanism of action, this study evaluated the chemopreventive activity of the me...

Four compounds previously described as antimutagenic for human lymphocytes in vitro were tested on their immunomodulatory activity in lymphocyte cultures. The standard immunocytochemical methods were applied for microscopic examination of the percentual representation of the main lymphocyte subpopulation. The results imply that all of the tested compounds exhibited significant immunomodulatory ...

Piperine is a major pungent substance and active component of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). Regarding the variable biological activities of piperine, it is important to study its antimutagenic activity in somatic and germ cells in vivo. Swiss albino male mice were orally administered piperine at the doses of 5, 10 and 15mg/kg b. wt. for three consecutiv...