PURPOSE Indapamide, a non-thiazide antihypertensive diuretic agent, has been widely coadministered with other classes of antihypertensive agents to reach target systolic blood pressure. Indapamide is extensively metabolized by cytochromes P450. Interaction of indapamide and other antihypertensive drugs are unknown. We investigated the effects of other antihypertensive drugs on the metabolism an...

Growth of Knowledge in the Nineteenth Century, 2742 The Measurement of Blood Pressure, 2743 Forerunners of Modern Treatment, 2743 Low-Salt Diets, 2743 Surgical Sympathectomy, 2744 The Beginnings of Drug Treatment, 2744 Ganglion-Blocking Drugs, 2745 Veratrum Viride, Hydrazaline, and Reserpine, 2746 The Modern Era of Antihypertensive Drugs, 2747 Thiazide Diuretics, 2747 Guanethidine and Alpha-Met...

Randomized clinical trials have shown that antihypertensive treatment reduces the risk of heart failure (HF). Limited evidence exists, however, on whether and to what extent this benefit is translated into real-life practice. A nested case-control study was carried out by including the cohort of 76 017 patients from Lombardy (Italy), aged 40 to 80 years, who were newly treated with antihyperten...

Clinical trials evaluating the effects of treatment with antihypertensive drugs on the prevention of the complications of hypertension have been limited almost exclusively to patients with severe hypertension. In malignant hypertension the life expectancy of the untreated patient seldom exceeds one or two years. The prolongation of life of many patients to five years or longer with antihyperten...

OBJECTIVE To determine the prevalence of hypertension, patterns of antihypertensive treatment and level of blood pressure control in adult Thai type 2 diabetic patients who attended diabetes clinics in university and tertiary-care hospitals. MATERIAL AND METHOD A cross-sectional, multi-center, hospital-based diabetes registry of 8884 adults 18 years old and older was carried out from diabetes...

BACKGROUND It is not known whether antihypertensive medications affect orthostatic blood pressure (BP) regulation in the early period after stroke. Knowledge of this may have implications for clinical practice. METHODS A total of 40 acute ischemic stroke patients (mild-to-moderate severity) taking antihypertensive drugs, and 40 patients with acute stroke of similar severity not receiving such...

Traditional Chinese patent medicine (TCPM) is widely used for essential hypertension (EH) in China. However, there is no critically appraised evidence, such as systematic reviews or meta-analyses, regarding the potential benefits and disadvantages of TCPM to justify their clinical use and recommendation. The aim of this review was to systematically evaluate and meta-analyze the effects of TCPM ...

Although recent data have suggested an association between renal cell cancer and the use of diuretics, it remains unclear whether these medications or hypertension is the important risk factor. In a population-based case-control study including 440 renal cell cancer cases, spouses of an additional 151 cases, and 691 controls, we assessed renal cell cancer risk associated with hypertension and u...

The purpose of this review was to evaluate the efficacy and safety of qigong for hypertension.A systematic literature search was performed in 7 databases from their respective inceptions until April 2014, including the Cochrane Library, EMBASE, PubMed, Chinese Scientific Journal Database, Chinese Biomedical Literature Database, Wanfang database, and Chinese National Knowledge Infrastructure. Ra...

BACKGROUND Although aerobic exercise has been shown to lower blood pressure (BP) in human beings, its additive BP-reducing effect on antihypertensive drug therapy seems to have been investigated in only laboratory animals. OBJECTIVES This study investigated the effects of aerobic dance combined with antihypertensive drugs on BP and number of antihypertensive drugs in individuals with hyperten...