The present study was undertaken to evaluate the antidiabetic and antihyperlipidemic activities of Allopolyherbal formulation (APHF) consisting of combinations of three well known medicinal plants used in traditional medicines (Trigonella foenum graceum, Momordica charantia, Aegle marmelos) and synthetic oral hypoglycaemic drug (Glipizide-GL). The optimized combination of lyophilized hydro-alco...

Ficus deltoidea is one of the common medicinal plants used in Malaysia. This epiphytic plant, from the Moraceae family has been claimed to have antidiabetic property. However, scientific evidence to confirm its efficacy is still lacking. The present study was undertaken to evaluate the effect of ethanolic extract of F. deltoidea on glucose level in normal rats at different prandial state. The r...

The array of medications available for the treatment of hyperglycemia has increased rapidly in the previous decade, and recent investigations have clarified novel mechanisms underlying the antihyperglycemic efficacy of these drugs. This article reviews the mechanisms of action for medications currently approved to treat diabetes mellitus in the United States, with the exception of insulin and i...

Essential oil (EO) obtained by hydrodistillation in a Clevenger-type apparatus from aerial parts of Nepeta cataria L. var. citriodora (Becker), cultivated Serbia was subjected to gas chromatography-mass spectroscopy (GC-MS) determine the composition. Furthermore, N. essential wastested its antimicrobial, antioxidant, antihyperglycemic and anti-inflammatory activities vitro.The antimicrobial act...

Diabetes mellitus drugs currently available are sulfonylureas, biguanides, thiazolidines, and alpha glucoside inhibitors which widely used to control hyperglycemia. These cannot prevent complications of diabetes, these should not be continuously because it causes undesirable pathological conditions. The essential oil in lime peel is rich phenolics, especially flavonoids, can oxidative stress. T...

Several new oral drugs have been approved for the management of type II diabetes. Metformin is an "antihyperglycemic agent" that decreases hepatic glucose production and improves insulin sensitivity. It may be used as monotherapy or in combination with a sulfonylurea. Acarbose slows carbohydrate absorption after a meal, giving endogenous or injected insulin more time to respond to ingested gluc...

Metformin is an antihyperglycemic agent commonly used in diabetic patients. It is very effective and is able to reduce the plasma glucose and HbA1C. However, in some patients, specially those with comorbidities, metformin can provoke severe lactic acidosis with high morbimortality. Treatment of the lactic acidosis induced by metformin is based on the use of supportive general measures; in sever...