The occurrence of variants of the erythrocyte B agglutinogen, although rare, is of considerable practical importance because it may lead to errors in blood grouping. Subgroups of the B antigen have not been established although variants have been described. Moullec and co-workers reported a weakly reacting B antigen in 1955. They named it B. In 1958 Levine and associates described the genetical...

B cell tolerance or autoimmunity is determined by selective events. Negative selection of self-reactive B cells is well documented and proven. In contrast, positive selection of conventional B cells is yet to be firmly established. Here, we demonstrate that developing self-reactive B cells are not always highly sensitive to the deletion mechanisms imposed by membrane-bound self-antigens. At low...

Abstract We identified the lowest composition necessary to generate a vaccination adjuvant that promotes Treg response following immunization in mice and named it “complete tolerogenic adjuvant.” This novel may allow us utilize well-established “antigen plus adjuvant” method of induce cell-mediated antigen-specific immunosuppression. The minimal is dexamethasone, rapamycin, monophosphoryl lipid...

Antigen-binding T and B lymphocytes were studied by combined autoradiography and immunofluorescence; mouse spleen lymphocytes binding the antigens, [(125)I]MSH or [(125)I]TIGAL, were incubated with rhodamine-labeled anti-Ig reagents or with a rhodamine-labeled IgG fraction of anti-theta serum. B cells were identified as Ig+ or theta-, T cells as Ig- or theta+. It was found that: (a) 20% (1-2 mo...

Papaevangelou, G., Kremastinou, T., Prevedourakis, C., and Kaskarelis, D. (1974). Archives of Disease in Childhood, 49, 936. Hepatitis B antigen and antibody in maternal blood, cord blood, and amniotic fluid. Transplacental transmission of hepatitis B virus from hepatitis B antigen carrier mothers was investigated by studying the presence of the antigen and its antibody in maternal blood, umbil...

Respiratory exposure to allergen induces the development of allergen-specific CD4(+) T cell tolerance that effectively protects against the development of allergic-sensitization and T(h)2-biased immunity. The establishment of T cell unresponsiveness to aeroallergens is an active process preceded by a transient phase of T cell activation that requires T cell co-stimulation and is critically infl...