Abstract Concerns about ozone layer, contamination, fossils resources and health, has banned or restricted the use of traditionally organic solvents in paints. As a consequence, new resins that employed water as main solvent are being studied. Among these resins, alkyds most studied one they can also be synthesised from natural vegetable sources, making them more acceptable. The aim this paper ...

During the search for a potent antifungal drug, a cell-permeable metabolite was isolated from a soil isolate taxonomically identified as Penicillium radicum. The strain was found to be a potent antifungal agent. Production conditions of the active compound were optimized and the active compound was isolated, purified, characterized and identified as a phosphoinositide 3-kinase (PI3K) inhibitor,...

Various soil samples were randomly collected at different places in south Delta, Egypt. A total of 105 Streptomyces isolates, were selected according to their morphological characteristics. Antifungal activity was assessed by agar well diffusion assay. Ten isolates showed antifungal activity against various reference strains of yeast and fungi. The maximum zone of inhibition was detected for As...

BACKGROUND Plagiochin E (PLE) is an antifungal macrocyclic bis(bibenzyl) isolated from liverwort Marchantia polymorpha L. Its antifungal mechanism is unknown. To elucidate the mechanism of action, its effect on mitochondria function in Candida albicans was studied. METHODS We assayed the mitochondrial membrane potential (mtDeltapsi) using rhodamine 123, measured ATP level in mitochondria by H...

We investigated the antifungal effect of dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucoside (DDDC9G) and its mechanism(s). Antifungal susceptibility testing showed that DDDC9G exhibted potent antifungal activities with almost no hemolytic effect. To understand the antifungal mechanism(s) of DDDC9G, we conducted the following experiments in this study using Candida albicans. Fluorescence exper...

Since current antifungal drugs have not kept pace with the escalating medical demands of fungal infections, new, effective medications are required. However, antifungal drug discovery is hindered by the evolutionary similarity of mammalian and fungal cells, which results in fungal drug targets having human homologs and drug non-selectivity. The group III hybrid histidine kinases (HHKs) are an a...

Fungi of the genus Paracoccidioides are responsible for paracoccidioidomycosis. The occurrence of drug toxicity and relapse in this disease justify the development of new antifungal agents. Compounds extracted from fungal extract have showing antifungal activity. Extracts of 78 fungi isolated from rocks of the Atacama Desert were tested in a microdilution assay against Paracoccidioides brasilie...