a new series of thiazolidinedione derivatives were synthesized. the structures of these compounds were established by means of ir, 1h-nmr and elemental analysis. all of the compounds were screened for antidiabetic activity on albino rats. most of the compounds showed significant antidiabetic activity when compared with the standard drug glibenclamide.

materials and methods the expression of hyaluronidase antigenic fragments was optimized using iptg concentration, time of induction, temperature, culture, and absorbance of 0.6-0.8-1 at 600 nm. afterwards, the expressed proteins were purified and the enzymatic activity was assessed by turbid metric method. results data indicated that maximum protein is produced in od = 0.8, 0.5 mm isopropyl β-d...

background:  physical activity is a complex behavior. to designing the effective intervention, qualitative researches may be allowed for greater understanding of the reasons behind the adolescences’ physical activity‑related behaviors’. methods: using the grounded theory approach, including semi‑structured focus group discussions  (fgds) and in‑depth interviews, we conducted a quantitative stud...

this study aimed to assess the anticariogenic and hemolytic activity of crude plant seed protein extracts against tooth decaying bacteria.the proteins from seeds of 12 different plants were extracted and used for antimicrobial assay against six different organisms. the extraction was carried out in 10mm of sodium phosphate buffer (ph 7.0). protein concentrations were determined as described by ...

caffeic acid phenethyl ester(cape) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. a group of heterocyclic esters of caffeic acid was synthesized using mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catechol...

pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. in this study, b3 p 86 / 6 – 31 + + g * was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. several statisti...

the complex metabolic syndrome, diabetes mellitus, is a major human health concern in the world and is estimated to affect 300 million people by the year 2025. several drugs such as sulfonylureas and biguanides are presently available to reduce hyperglycemia in diabetes mellitus. these drugs have side effects and thus searching for a new class of compounds is essential to overcome this problems...

the whole plant, pergularia daemia (family: asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. the diuretic activity of the different extracts at a dose of 400 mg/kg was assessed orally in rats with furosemide as a standard drug using lipschitzs t...

background: recent studies have shown that physical activity is an effective factor in improving sleep quality. therefore, this study aimed to compare the sleep quality of athlete and non-athlete pregnant women. methods: this cross-sectional descriptive analytical study was performed on 300 pregnant women in the last trimester of pregnancy, referred to prenatal care unit of amiralmomenin hospit...

the ethanolic extract of ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic albino rats induced via carbon tetrachloride. the degree of protection was measured by estimating biochemical parameters such as serum glutamate oxaloacetate transaminase (sgot), serum glutamate pyruvate transaminase (sgpt), total protein (tp), total albumin (ta), alkaline phos...