Diffuse glomerulonephritis was induced in unilaterally nephrectomized albino rabbits by giving them two massive intravenous injections of purified bovine serum gamma globulin. Morphologically, these renal lesions were similar to those of human acute and subacute glomenilonephritis. Globulin nephritis in rabbits also closely resembles experimental nephritis induced by injection of other foreign ...

The effect of woundingand formation of regenerating wound tissueon the level of the serum proteins was studied in rats on a protein-free diet. It was found that the level of the globulin component having the third greatest electrophoretic mobility, probablypart of the a,-globulin fraction, roseabout 60% within 3 days after wounding and did not begin to return to normal until about 10 days later...

An automated continuous-flow procedure has been developed for simultaneously measuring total serum protein and globulin. The method for total protein is a minor modification of an existing automated method in which the biuret reagent is used. Total globulin is measured by reaction with glyoxylic acid, and standardized with N-acetyltryptophan. An empirical factor relating concentration of N-acet...

Purification of the activity of the fourth component of human complement resulted in the isolation of a highly homogeneous serum protein. Since this protein has not been recorded previously it was called beta(1E)-globulin on the basis of its immunoelectrophoretic behavior. C'4 activity and beta(1E)-globulin were found to have highly similar, if not identical physicochemical characteristics. Mor...

In an earlier communication (1) attention was called to the marked depressions of albumin: globulin ratios that frequently occur in the course of louse-borne typhus fever. Serum globulin concentrations in a number of cases were found to be higher than 5 grams per 100 ml. Because of the consistent rise in serum globulins in this disease, possibly a feature of the immune response, it was of inter...

An attempt is made to describe the nature of the chemical interactions participating in blood clotting. In the laboratory, thrombin can be derived directly from prothrombin without the physiologic activators calcium, thromboplastin, Ac-globulin, and platelet derivatives. The newly recognized clotting factor, Ac-globulin, is essential for normal physiologic hemostasis. Plasma Ac-globulin concent...

The long-standing observations that respiratory secretions contain virus-neutralizing substances (1-3) have recently been extended by the demonstration that antibody activity associated with the yA-globulin in nasal secretion may protect against respiratory virus infection (4). Since protection was most clearly seen in individuals with relatively high titers of nasal antibody, and since yA-glob...

An attempt is made to describe the nature of the chemical interactions participating in blood clotting. In the laboratory, thrombin can be derived directly from prothrombin without the physiologic activators calcium, thromboplastin, Ac-globulin, and platelet derivatives. The newly recognized clotting factor, Ac-globulin, is essential for normal physiologic hemostasis. Plasma Ac-globulin concent...

Serum protein concentrations provide insight into the nutritional and immune status of organisms. It has been suggested that some marine turtles are capital breeders that fast during the nesting season. In this study, we documented serum proteins in neophyte and remigrant nesting leatherback sea turtles (Dermochelys coriacea). This allowed us to establish trends across the nesting season to det...

Hypophysectomy is known to cause complete suppression of the hepatic synthesis az,-globulin. The effect of hypophysectomy on the synthesis of azu-globulin can be reversed by multiple hormone treatment. The role of pituitary growth hormone in the multihormonal regulation of aZ,-globulin in rat liver was examined in the hypophysectomized male rats with and without growth hormone supplementation. ...