This study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (TS) inhibitor. The designed scaffold is a combination of nucleobase, amino acid and aziridine structures. The candidates are docked into TS and three DNA double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

Dasatinib is a tyrosine kinase inhibitor (TKI) that is used to treat chronic myeloid leukemiaand in the management of ulcerative colitis (UC) and to provide appropriate results in treatment. Dasatinib is significantly higher and faster than full cytogenetic and large molecular responses as compared to imatinib. In the recent study, using the NMR data, thermochemical properties of the dasa...

Vitamin E isoforms have been extensively studied for their anticancer properties. Novel drug delivery systems (DDS) that include liposomes, nanoparticles, and micelles are actively being developed to improve Vitamin E delivery. Furthermore, several drug delivery systems that incorporate Vitamin E isoforms have been synthesized in order to increase the bioavailability of chemotherapeutic agents ...

Mouse leukemia models were a central component of the initial drug discovery programs employed by the Division of Cancer Treatment (DCT) of the National Cancer Institute (NCI) during the early 1960s and 1970s. The L1210 and P388 leukemias, developed in 1948 (1) and 1955 (2), respectively, played a major role in both screening and detailed evaluations of candidate anticancer agents. Today, 40 yr...

As versatile drug delivery systems, polymeric micelles have demonstrated particular strength in solubilizing hydrophobic anticancer drugs while eliminating the use of toxic organic solvents and surfactants. However, the true promise of polymeric micelles as drug carriers for cancer therapy resides in their potential ability to preferentially elevate drug exposure in the tumor and achieve enhanc...

The construction of synthetic straightforward, biocompatible and biodegradable targeted drug delivery system with fluorescent tracking abilities, high anticancer activities and low side effects is still a challenge in the field of biochemistry and material chemistry. In this work, we constructed targeted paclitaxel (Taxol) delivery nanoparticles composed of permethyl-β-cyclodextrin modified hya...

Traditional anticancer therapy involves treatment with radiation and DNA-damaging chemotherapies. More recently, insight into the molecular and genetic changes associated with cancer has led to a shift in anticancer drug development, and new drugs typically modulate specific molecular targets associated with onset and progression of the disease. The oncologist’s armamentarium has thus expanded ...

Nowadays apphcanon of nanotubes in biology and medicinal science is more investigated. Nanotubes can passthroueh cell walls and transport and release drugs in special tissues. The purpose of this paper is to investigatethe interaction of a nanotube having hydroxyl functional groups (OH) with an anticancer agent. In this worktransporting of an anticancer drug named 2-(2-amino 6,7-dimethyl Pterid...

At present, effective anticancer therapy remains one of the most challenging tasks facing the scientific community. A major limitation to most conventional low-molecular weight anticancer chemotherapeutics is their unfavourable uptake by healthy tissue, fast metabolism and lack of tumour cell selectivity. One way to solve this problem is the application of hybrid nanoparticles containing widely...

Renal insufficiency has been shown to be highly prevalent in patients with cancer. This renal insufficiency has been reported to be associated with reduced overall survival and increased cancer-related mortality. Therefore, it is important to screen patients with cancer for renal insufficiency, using an adequate and reliable method of estimation of the renal function. Renal insufficiency may in...