Background Small children with dilated vesicoureteral reflux (VUR) run risk of recurrent urinary tract infections (UTI) and to acquire renal damage. To protect them, antibiotic prophylaxis and surgery to eliminate VUR have been used. Endoscopic injection of bulking agent at the ureteral orifice has evolved as alternative surgical method but with insufficient scientific support of long term effe...

Background: Surgical drainage and antibiotic therapy are the cornerstones of treatment protocols in septic arthritis; however, in some circumstances, the diagnosis and initiation of treatment may be retarded by slow disease progression or the time when the patient’s condition precludes early surgery. Therefore, it is beneficial to find ways to reduce the amount of articular injury. This study a...

INTRODUCTION: According to the data by World Health Organization, broad and often insufficiently substantiated prescription of antibiotics, including for prophylactic purposes, has led growth antibiotic-resistant microflora, which is a dangerous intractable problem modern medicine. Despite undoubted benefits antibiotics in management wound infection endometritis after cesarean section, routine ...

Scientific relevance. A promising option for dysbiosis correction is the use of metabiotics, products based on metabolites probiotic microorganisms. During fermentation, Bacillus subtilis bacteria (strains 3H and 1719) produce that exhibit properties in vitro . These observations motivate an vivo investigation B. metabolite effects colonic mucosal microbiota mice experimentally induced assessme...

The frequency of three mitochondrial point mutations, 1555A-->G, 3243A-->G, and 7445A-->G, known to be associated with hearing impairment, was examined using restriction fragment length polymorphism (RFLP) analysis in two Japanese groups: (1) 319 unrelated SNHL outpatients (including 21 with aminoglycoside antibiotic injection history), and (2) 140 cochlear implantation patients (including 22 w...

DNA vaccines represent a new approach to protect against infectious disease, and hence may improve human and animal welfare, reduce antibiotic usage and reduce the spread of pathogens. Edible and injectable DNA vaccines hold prospects for rapid immunization against a variety of diseases that are difficult to eradicate with traditional vaccines and antibiotics. Other potential uses of DNA vaccin...

Abstract Although antibiotics are clinically crucial, little is known about how they impact a patient’s immune response to infection. We address that gap by investigating macrophages respond bacteria treated with different classes of antibiotics. broadly susceptible E. coli strain 8 separate antibiotics, infected macrophages, and compared much TNF the various antibiotic-treated elicited from ma...

The pharmacokinetic properties of cefuroxime have been evaluated in laboratory animals. On injection into mice, rats, and rabbits by the subcutaneous or intramuscular routes, high serum level peaks were recorded. There was no significant absorption after oral administration. After injection, the antibiotic was excreted in large amounts in the urine. It was well distributed in the body and penet...

Data are presented, demonstrating that infection with Rickettsia typhi brings about a reduction of the death rates and a prolongation of the time of survival in animals subsequently challenged with Pasteurella pestis or Pasteurella tularensis. This interference with bacterial infection by previous rickettsial infection does not appear immediately after injection of the rickettsiae; it begins to...