Optimized nutrition through supplementation of diet with plant derived phytochemicals has attracted significant attention to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. These phytonutrients alone or in combination with others are believed to impart beneficial effects and play pivotal role in metabolic abnormalities such as dys...

he phenomenon of antiangiogenesis has attracted considerable interest in the scientific community. Angiogenesis plays a major role as a determining factor in a variety of diseases, including: cancer, arthritis, skin conditions, eye disorders, and inflammatory disease. The application of methods to manipulate angiogenesis has created fascinating therapeutic options, including the potential of na...

Purpose: MET signaling has been suggested a potential role in hepatocellular carcinoma (HCC) and associated with prometastasis during antiangiogenesis therapy. We investigated the potential association between MET expression and therapeutic response to sorafenib in patients with HCC. Antitumor effects of cabozantinib, a dual inhibitor of MET and VEGFR2, were examined in cultured HCC cells as we...

A practical and modular approach to obtain a diverse set of 14-membered macrocyclic compounds from carbohydrates is developed that utilizes functional groups at C-1 and C-5. The evaluation of this toolbox in various zebrafish assays led to the identification of 2.7f as an antiangiogenesis agent.

It has been shown that endothelial cells in solid tumors are cytogenetically abnormal. These cells are aneuploid with multiple chromosomes and multiple centrosomes. Unlike normal endothelial cells which remain diploid in long-term culture, the aneuploidy of tumor endothelial cells is exacerbated in culture suggesting that these cells are inherently unstable. It is speculated that this instabili...

p53 is a key tumor suppressor gene that is targeted for inactivation during human tumorigenesis. In this study, we produced and characterized polyclonal antihuman p53 antibody. The cDNA encoding the completehuman p53 protein was cloned into pGEX-4T-1 and expressed in Escherichia coli as a fusion protein with Schistosoma japonicum glutathione S-transferase (GST). The rabbits were immunized...

Abstract BACKGROUND Glioblastoma (GBM) is one of the most malignant primary brain tumors. Despite development treatment, prognosis GBM still poor. Here, we identified lomerizine, a prophylactic drug for migraine, as potential anti-GBM from thousands existing compounds. We investigated its therapeutic effects both in vitro and vivo with purpose repositioning. Materials method: Human patient-deri...