OBJECTIVE To assess the frequency of primary drug resistance among newly diagnosed tuberculosis cases in Karachi. STUDY DESIGN Cross-sectional study. PLACE AND DURATION OF STUDY Multicentric study involving various TB clinics and treatment centres of Karachi between April to December 2005. METHODOLOGY The frequency of drug resistance among new TB patients was evaluated using a non-probabi...

a 24‑year‑old, unmarried woman diagnosed of pulmonary tuberculosis (ptb) visited our hospital out‑patient department in the month of august‑2013. patient came with the complaint of sever cough with expectoration; evening raise of temperature; gradual loss of appetite and weight since 2‑weeks. we referred the patient to our hospital’s revised national tuberculosis program, direct observed treatm...

A 24 year university student with history of productive cough was registered as sputum smear confirmed case of pulmonary tuberculosis. During treatment, patient suffered from itchiness associated with anti tuberculosis drugs and was treated with chlorpheniramine (4mg) tablet. Patient missed twenty eight doses of anti tuberculosis drugs in continuation phase claiming that he was very busy in his...

Tuberculosis (TB) is a major global health problem. Patients with TB have a high rate of vitamin D deficiency, both at diagnosis and during the course of treatment with anti-tuberculosis drugs. Although data on the efficacy of vitamin D supplementation on Mycobacterium tuberculosis (Mtb) clearance is uncertain from randomized controlled trials (RCTs), vitamin D enhances the expression of the an...

background bcg (bacille calmette-guerin) vaccine is an attenuated live vaccine administered to prevent tuberculosis. disseminated infection due to bcg is a rare life threatening complication of this vaccine, especially in immunocompromised patients. objectives the current study evaluated the sensitivity pattern of the bcg strain supplied by the institute de pasteur, iran against anti-mycobacter...

BACKGROUND & OBJECTIVES Studies have shown the bactericidal potential of econazole and clotrimazole against Mycobacterium tuberculosis under in vitro and ex vivo conditions along with their synergism with conventional antituberculosis drugs. These molecules were also found to be effective against different multidrug resistant (MDR) M. tuberculosis isolates in vitro. Hence the present study was ...

Introduction: Tuberculosis is still commonly found in many developing countries. Spinal tuberculosis can cause vertebral deformity and neurological disorders. It was discovered thousands years ago its management aimed to eradicate infection maintain the integrity of vertebrae. Previously, spinal TB using drugs external stabilization. Surgical techniques were developed afterwards clean infected ...

An unprecedented number of investigational drugs are in the development pipeline for the treatment of tuberculosis. Among patients with tuberculosis, co-infection with HIV is common, and concurrent treatment of tuberculosis and HIV is now the standard of care. To ensure that combinations of anti-tuberculosis drugs and antiretrovirals are safe and are tested at doses most likely to be effective,...