background: mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. antineutrophil cytoplasmic antibodies (anca's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculit...

BACKGROUND Opportunistic infections are relatively rare in early human immunodeficiency virus infection, especially infection with Mycobacterium tuberculosis. Here, we report a patient who presented with acute human immunodeficiency virus and multidrug-resistant M. tuberculosis co-infections. CASE PRESENTATION A 27-year-old homosexual male was admitted for fever, cough, and hepatitis. At the ...

background: resistance to anti-tuberculosis (tb) drugs is a global problem. previous studies showed that the prevalence of primary mdr-tb is higher and has been increasing. the purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-tb drugs. methods: in this cross-sectional study, 266 smear positive pulmo...

Tuberculous glycolipid (TBGL) antigen is a cell wall component of Mycobacterium tuberculosis and has been used for the serodiagnosis of tuberculosis. We investigated correlations between the levels of anti-TBGL antibodies and a variety of laboratory markers that are potentially influenced by tuberculous infection. Comparisons between patients with cavitary lesions and those without cavitary les...

tuberculosis (tb) is the most common infectious cause of human death. after the lung, genitourinary tract is the most common site for tb infection. pelvic tuberculosis should be considered in young women presented with pelvic mass, ascites, fever, an elevated ca125 level, negative cytology, and positive history of contact with affected person. a 24- year- old girl presented as stage iv ovarian ...

lamina propria (Figure 2B). The autoantibodies were not significantly increased. Anti-tuberculosis treatment was stopped, and the patient was started on methylprednisolone. This treatment relieved his skin lesions, abdominal pain. Follow-up esophagogastroduodenoscopy showed complete disappearance of all mucosal lesions. The patient fully met the criteria for CLV, as he was >16 years of age and ...

Mycobacterium tuberculosis is a leading cause of morbidity and mortality worldwide. Mycobacterium tuberculosis infects about one third of world population and tuberculosis remains the most frequent cause of death due to a single infectious disease. Anciently, herbal plants have established home remedies for many of common alignments, diagnostic procedures and preventive measures. Using this str...

BACKGROUND Screening and treatment of latent tuberculosis infection (LTBI) prior to anti-tumour necrosis factor alpha (anti-TNF-alpha) therapy has been shown to decrease the incidence of active tuberculosis (TB) by more than 80%, and is recommended by the British Thoracic Society. In the absence of a gold standard test for LTBI, conventional screening currently involves taking a clinical histor...

Background: Mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. Infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. Antineutrophil Cytoplasmic Antibodies (ANCA's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculitic sy...

The interaction between the mycobacterial thioredoxin reductase (TrxR) and its substrate thioredoxin (Trx) is a promising new drug target for the treatment of tuberculosis, since Mtb lacks the common glutathione system and the mycobacterial TrxR shows a substantial difference in sequence, mechanism and structure to human TrxRs. It was shown that TrxR is essential for thiol redox homeostasis and...