Sphingosine 1-phosphate (S1P) is a pleiotropic lysosphingophospholipid stored and secreted by platelets. Using reverse transcription-polymerase chain reaction and flow cytometric analyses, we determined the expression of S1P receptors (S1P1, S1P3, S1P4, and S1P5) in peripheral blood T cells. T cells were induced to proliferate in the presence of phorbol 12-myristate 13-acetate (PMA) plus ionomy...

Abstract BACKGROUND Glioblastoma (GBM) is one of the most malignant primary brain tumors. Despite development treatment, prognosis GBM still poor. Here, we identified lomerizine, a prophylactic drug for migraine, as potential anti-GBM from thousands existing compounds. We investigated its therapeutic effects both in vitro and vivo with purpose repositioning. Materials method: Human patient-deri...

Breast cancer is one of the most lethal malignancies in women worldwide and characterized by rapid growth low survival rates, despite advances tumor biology therapies. Novel therapeutic approaches require new insights into molecular mechanisms malignant transformation progression. To this end, here, we identified Prox1 as a negative regulator proliferation tumor-related metabolism breast cancer...

Natural bioactive compounds that trigger apoptosis in medicinal plants might be a promising new source of anti-cancer medications. The present study aimed to assess the potential powerful therapeutic plant Chrysanthemum indicum. whole extract was extracted n-hexane and ethanol solvents test anticancer antioxidative capabilities on cancer HepG2 cell line. cells untreated group had not been expos...

Cajanus cajan (L.) Millsp., known as pigeon pea, C. Millsp. roots (CR) contain daidzein, genistein, and cajanol which have numerous health benefits. The aim of this study was to investigate the anti-proliferative anti-metastatic effects sub-fractions (EECRpw, EECRp25, EECRp50, EECRp70, EECRp95) containing 95% ethanol extract from CR (EECR95) in oral squamous cell carcinoma cells (SCC25). We fou...

Abstract The current study evaluated the anti-cancer properties of bio-functionalized silver nanoparticles fabricated by Juniperus chinensis leaf extracts. were characterized scanning electron microscopy, transmission UV–visible spectroscopy, Fourier transform infrared X-ray diffraction, dynamic light scattering, Zeta potential and spectroscopy. Further, this elucidated cellular molecular mecha...

Traditional Chinese medicine (TCM) has been increasingly employed in the last decades China for both preventing and treating a variety of cancers. 3-epi-bufotalin is an active ingredient TCM “Chanpi” with anti-tumor potential. However, effect mechanism on colorectal cancers were not well disclosed. The present study demonstrated that could reduce viability, trigger apoptosis, block cell cycle a...

UNLABELLED BACKGROUND Benzimidazole derivatives are structurally bioisosteres of naturally occurring nucleotides, which makes them compatible with biopolymers of living systems. This property gives benzimidazole a biological and clinical importance. In the last decade, this class of compounds has been reported to possess anti-allergic, anti-diabatic, anti-HIV, anti-hypertensive, anti-inflamm...