INTRODUCTION Studies investigating genetic risk factors for susceptibility to rheumatoid arthritis (RA) studied anti-citrullinated peptide antibody (CCP)-positive RA more frequently than anti-CCP-negative RA. One of the reasons for this is the perception that anti-CCP-negative RA may include patients that fulfilled criteria for RA but belong to a wide range of diagnoses. We aimed to evaluate th...

Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of antibodies against cyclic citrullinated peptide (anti-CCP), a consequence of the breakdown of immune tolerance. The lymphoid tyrosine phosphatase (Lyp) protein has significant effects on maintenance of peripheral immune tolerance. Two polymorphic variants (-1123G>C and +1858C>T) at PTPN22 gene that encodes this ...

INTRODUCTION Radiographic progression in rheumatoid arthritis (RA) has in several studies been shown to be predicted by serological markers widely used in daily clinical practice. The objective of this longitudinal study was to examine if these serological markers also predict hand bone mineral density (BMD) loss in patients with RA of short disease duration. METHODS 163 patients with RA of s...

We studied the diagnostic value of high-frequency color Doppler ultrasonography (HCDU) examination in combination with anti-cyclic citrullinated peptide (anti-CCP) antibody testing in rheumatoid arthritis (RA) patients with finger joint damage. From January 2015 to December 2015, 80 patients diagnosed with RA with finger joints damage were enrolled in this study. Patients were examined with HCD...

Correspondence to Dr Kim S Midwood; [email protected]. ac.uk Early treatment of rheumatoid arthritis (RA) results in more effective disease suppression and can be key to a successful patient response. However, not all people who exhibit early synovitis develop RA; for example, in some, synovial inflammation resolves spontaneously. The factors that drive RA development remain unclear and cl...

OBJECTIVE To investigate whether determination of a set of laboratory markers at baseline provides prognostic information on joint damage in hands and feet in rheumatoid arthritis. METHODS 183 patients with early rheumatoid arthritis included in a prospective study were examined. Radiographic changes in hands and feet at 5 and 10 years after inclusion were evaluated (Larsen). The markers anal...

INTRODUCTION Although many studies have suggested that the presence of autoantibodies, such as rheumatoid factor (RF) and/or anti-cyclic citrullinated peptide (anti-CCP) in rheumatoid arthritis (RA) are predictors of joint damage, the association with disability and quality of life questionnaires are not known. OBJECTIVES To evaluate the correlation between the Health Assessment Questionnaire...

regarding the infl uence of anti-cyclic citrullinated peptide (CCP) on anticentromere antibody (ACA)-positive patients suff er ing from rheumatoid arthritis (RA) [1]. Th eir fi ndings explore the eff ect of ACA positivity in a patient group diff erent from the cohort of primary Sjögren syndrome (SS) patients we chose to study [2]. Due to the diff erent study population and the retrospective nat...

'Rhupus' is a rare condition sharing features of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). If rhupus is a distinctive entity, an overlap between RA and SLE or a subset of SLE is currently debated. This study was performed to explore the prevalence of antibodies against cyclic citrullinated peptides (anti-CCP antibodies) in rhupus. Patients meeting American College of Rhe...

Purpose: To evaluate the protective effects of chestnut (Castenea cranata Siebold & Zucc., Fagaceae) peel extract on stimulated BV-2 microglial cells as well as its anti-oxidant properties. Methods: The ethyl acetate fraction of C.cranata peel (CCP) extract was used in the study to evaluate the anti-neuroinflammatory effects in BV-2 microglial cells. Cell viability was performed by 3-(4, 5dimet...