A recombinant plasmid carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1) linked to the reporter chloramphenicol acetyl transferase (CAT) gene was stably introduced into human fibroblasts. The transfectant cells expressed CAT activity from the HIV LTR. The response to anti-neoplastic drugs, i.e. cisplatin, a platin derivative, and hexadecylphosphocholine, was s...

BACKGROUND There is currently no effective AIDS vaccine, emphasizing the importance of developing alternative therapies. Recently, a patient was successfully transplanted with allogeneic, naturally resistant CCR5-negative (CCR5Delta32) cells, setting the stage for transplantation of naturally resistant, or genetically modified stem cells as a viable therapy for AIDS. Hematopoietic stem cell (HS...

Pyrazole is associated with wide range of biological properties. These ring systems are incorporated into drugs used for AIDS, cancer, anti-viral treatment etc. Pyrazole derivatives are well established in the literature as important biologically active compounds. They have a long history of application in agrochemicals and pharmaceutical industry as herbicides and active pharmaceuticals. Pyraz...

HIV (human immunodeficiency virus) infection may produce no clinical symptoms for 10 years on average. However, after many years of infection most people develop symptoms that indicate progression of the disease. There are no regular characteristic symptoms or early stage, and no logical sequence of AIDS indicator disorders has been observed. People who are not aware of the infection are referr...

background the evidence of rapid spread of multidrug resistant mycobacterium tuberculosis (mdr–tb) strains especially in high risk communities, persuade clinicians to find new drugs for this problem. β– lactams with few or no side effects has been reviewed as an alternative drugs for this issue. this study carried out to determine the effectiveness of amoxicillin–clavulanate in a group of irani...

Accelerated chemotherapy 1444 Acquired resistance 1064 ADCC 463 Adenocarcinomas 1023, 1153, 1371, 1781 Adenomatous polyposis coli 69, 98 Adjuvant chemotherapy 827, 1251 Adjuvant therapy 1437 Advanced breast cancer 141 Advanced gastrointestinal cancer 1265 Aetiology 1667 Ageing 930 Aggressive fibromatosis 98 AIDS 1298 Alcohol 46, 341, 678 Alcohol intake 1700 ALIMTA 649 Allelic imbalance 1201 Alp...