Tropical Spastic Paraparesis/HTLV-1 Associated Myelopathy (TSP/HAM) is clinically characterized by chronic insidious spastic paraparesis associated with variable sensory impairment and sphincter symptoms. Neuropathological studies of this condition are based on a few autopsied cases, and on experimental animal models. However, divergent aspects exist between human and experimental animal neurop...

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The assessment of pain, distress and suffering, as well as evaluation of the efficacy of stress-reduction strategies, is crucial in animal experimentation but can be challenging in laboratory mice. Nest building and burrowing performance, observed in the home cage, have proved to be valuable and easy-to-use tools to assess brain damage or malfunction as well as neurodegenerative diseases. Both ...

M artinière et al. (1), at long last, take a critical look at the general mobility of proteins in the plant plasma membrane. Hundreds of studies looking at the active or diffusion-limited transport of proteins in the animal cell plasma membrane paint a complex picture. There are mammalian proteins that wander the membrane aimlessly, proteins corralled into pens by the cytoskeleton, proteins tha...

background continuous epidural analgesia with catheterization is a useful technique, because it has a wide adaptation range and provides prolonged analgesia. problems that may arise from long-term epidural analgesia are changes in the analgesic area, duration of analgesia and catheter-related problems. few articles have evaluated gradual changes of long-term epidural analgesia. in the animal mo...