January 2009 Version 9 TEMPORAL LOBE EPILEPSY: A CLINICAL VIEW POINT Background: Temporal lobe epilepsy (TLE) was defined in 1985 by the International League Against Epilepsy (ILAE) as a condition characterized by recurrent unprovoked seizures originating from the medial or lateral temporal lobe. The seizures associated with TLE consist of simple partial seizures without loss of awareness (with...

Twenty five children each with temporal lobe epilepsy and grand mal epilepsy, both diagnosed electroencephalographically were studied for psychiatric disorders. Temporal lobe epileptics had such disturbances much more oftener. The commonest diagnostic label in both the groups was behaviour disorder, followed by neuroses. Schizophrenia was seen only in temporal lobe epileptics.

BACKGROUND Electrical brain stimulation has shown promise for reducing seizures in drug-resistant epilepsy, but the electrical stimulation parameter space remains largely unexplored. New stimulation parameters, electrode types, and stimulation targets may be more effective in controlling seizures compared to currently available options. HYPOTHESIS We hypothesized that a novel electrical stimu...

Peri-ictal water drinking (PIWD) is a rare vegetative manifestation of temporal lobe epilepsy without definite lateralization value. We report case PIWD in 22-year-old Omani man with post-concussion syndrome and presented to tertiary care hospital Muscat, Oman 2021 for evaluation paroxysmal events. His behaviour was misinterpreted by his family until characterized the epilepsy-monitoring unit a...

CCL3 and CCL4 are proinflammatory chemokines belonging to the CC family. Increase in expression of mRNA coding for various chemokines including CCL3 and CCL4 has been often detected with global transcriptome profiling of brain tissue following epileptogenic stimuli as well as in epilepsy in experimental models and in human patients. Despite this, little is known about the expression of these pr...

BACKGROUND AND PURPOSE The development of resistance to antiepileptic drugs is explained well by the transporter hypothesis, which suggests that drug resistance is caused by inadequate penetration of drugs into the brain barrier as a result of increased levels of efflux transporter such as p-glycoprotein. To evaluate the brain expression of p-glycoprotein in patients with drug-resistant epileps...

The endocannabinoid system modulates neuronal excitability, protects neurons against hyperexcitability and is involved in epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis. We performed in vivo positron emission tomography imaging of the type 1 cannabinoid receptor in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. Twelve patien...

Epilepsy is a common neurological disorder, about 1% population worldwide suffered from this disease. In 1989, the International League Against Epilepsy (ILAE) classified anterior cingulate epilepsy as a form of frontal lobe epilepsy (FLE). FLE is the second most common type of epilepsy. Previous clinical studies showed that FLE account an important cause in refractory epilepsy, therefore to fi...