The classic recommended antifungal agents for the treatment of invasive Candida infections were amphotericin B, a lipid formulation of amphotericin B and fluconazole in both neutropenic or nonneutropenic patients as either primary or alternative therapies. Voriconazole has been recommended when additional coverage for filamentous fungi is needed (e.g. neutropenic patients). More recently and ba...

The etiology of cardiomyopathies are classified into 4 main groupings (dilated, hypertrophic, restrictive, and idiopathic) and can be mechanistically caused by myocarditis, conduction abnormalities, focal direct injury, or nutritional deficiency. Based on our review of this topic, evidence suggests that echinocandin-related cardiac dysfunction is a mitochondrial drug-induced disease caused by f...

M e t h o d s Design: Randomized, controlled, noninferiority trial. Allocation: {Concealed}†.* Blinding: Blinded.* Setting: 47 institutions in 6 countries in Europe and North America. Follow-up period: 6 weeks after completion of therapy. Patients: 261 patients ≥ 16 years of age who had candidemia (≥ 1 positive blood culture) or other forms of invasive candidiasis (a positive culture obtained f...