BACKGROUND AND METHODS The aim of this study was to develop an immediate-release pellet formulation with improved drug dissolution and adsorption. Carbamazepine, a poorly water-soluble drug, was adsorbed into mesoporous silica (SBA-15-CBZ) via a wetness impregnation method and then processed by extrusion/spheronization into pellets. Physicochemical characterization of the preparation was carrie...

The objective of this study is to develop crystallo-co-agglomeratesof metronidazole having improved physicochemical, compressibility andsolubility properties. process agglomeration employed the use ofdichloromethane (good solvent), ethanol (bridging liquid) and distilled water (poorsolvent). Micromeritic properties co-agglomerates werestudied in terms bulk density, tapped Carr's index, Hausner’...

OBJECTIVE Assess the ability of facial reanimation surgery to restore affect display in patients with severe facial paralysis. STUDY DESIGN Survey of healthy observers' perception of change in facial visage from preoperative to postoperative state. SETTING Academic tertiary referral center. MAIN OUTCOME MEASURES Observer graded affect display. METHODS Ninety naive observers completed a ...

Aiming at the lack of accurate and reliable discrete element simulation parameters in study soilmachine interaction mechanism design machinery planting areas rhizomes hilly mountainous areas, EDEM software was used to calibrate parameters. The soil angle repose test contact between particles, sliding machinery. Box-Behnken optimization method establish multiple regression model angle, optimal p...

statement of problem: the goal of a successful endodontic surgery is to establish an adequate seal in apical region. therefore during surgery, root-end resection is essential for an appropriate situation and proper access.purpose: the aim of this study was to determine the most appropriate root-end resection angle to establish adequate apical seal in periapical surgerymaterials and methods: for...

Objective: Evaluate the physical-chemical properties and characterize microstructure of four varieties traditional Mexican chili (Capsicum annuum L.) powders: “Arbol”, “Guajillo”, “Piquin” “Mole ranchero” (Ancho chili).
 Design/methodology/approach: Physical-chemical powders were evaluated by means moisture content, particle size, aerated tapped bulk density, Carr index, Hausner ratio, ang...

Background. Tablets are still the most preferred means of drug delivery. The search for new and improved direct compression tablet excipients is an area research focus. This because method overcomes drawbacks granulation methods production. It exempts several treatment steps associated with methods. requirements powders to be directly compressible include flowability, low friction tendency, com...

Zanthoxylum bungeanum is a characteristic spice in culinary culture. This article focuses on the lack of intrinsic and contact parameters for studies discrete element tribute pepper from Hanyuan. to provide support mechanized harvesting bungeanum. The EDEM software was used establish model granules. granules, such as Three-dimensional dimension, density, Poisson’s ratio, elastic modulus, were m...

Objective The construction method of the discrete element model and setting simulation parameters in strip- blade-shaped sugarcane leaf are unclear. model’s accuracy greatly influences dynamic response characteristics between particles, it is necessary to improve through parameter calibration. Method optimized calibrated based on surface methodology (RSM) with physical angle repose as value. Fi...