PURPOSE The present study was designed to determine the association of polymorphisms of the DNA repair genes X-ray cross-complementing group 1 (XRCC1) (c.1316G>A [rs25487]) and xeroderma pigmentosum complementation group D (XPD) (c.2298A>C [rs13181]) with primary open-angle glaucoma (POAG) and primary closed-angle glaucoma (PCAG). METHODS In this prospective case-control study, polymerase cha...

INTRODUCTION To describe the optic disc, visual field and ocular characteristics of a consecutive cohort of Asian patients with chronic primary angle-closure glaucoma (CPACG), and compare them with those having primary open-angle glaucoma (POAG). METHODS In a prospective comparative case series of new patients with POAG or CPACG in Singapore, all patients underwent visual acuity assessment, s...

Glaucoma is a major cause of blindness worldwide. A single nucleotide polymorphism of the MTHFR gene (C677T) has been associated with susceptibility to this disease, although this is controversial in the last decade. In this study, the possible association between the MTHFR C677T polymorphism and the risk of developing primary open angle (POAG) and pseudoexfoliation glaucoma (PEXG) was investig...

This research examines the timeline of discovery and Primary Open-Angle Glaucoma (POAG). By reviewing literature on genetic molecular mechanisms, we aim to emphasize a long-term treatment solution (iSTENT) mitigate intraocular pressure (IOP) related POAG etiology disease progression. is multifactorial, autosomal dominant, adult-onset eye wherein optic nerve cells become damaged due buildup exce...

Glaucoma is the leading cause of irreversible blindness globally, with Primary open angle glaucoma (POAG) being commonest subtype. POAG characterized by an increase in intraocular pressure (IOP), to optic nerve damage and subsequent visual field defects. Despite clinical burden this disease poses, current therapies aim reduce IOP rather than targeting underling pathogenesis. Although pathogenes...

PURPOSE To determine the proinflammatory cytokine profile of aqueous humor from glaucomatous eyes. METHODS Aqueous humor samples were prospectively collected from 38 eyes (26 primary open angle glaucoma [POAG] and 12 primary angle closure glaucoma [PACG] eyes) of 37 medically treated glaucoma patients and 23 cataract subjects recruited in an institutional setting in this case-controlled study...

PURPOSE Recently, the neurotrophin-4 (NTF4), VAV2 and VAV3 genes have been implicated in primary open-angle glaucoma (POAG) in the European and Japanese populations, respectively. This study was conducted to determine their involvement in an Indian population with POAG and primary angle-closure glaucoma (PACG). METHODS The entire NTF4 gene and the POAG-associated SNPs rs2156323 (VAV2) and rs2...

PURPOSE To assess whether or not the c.677C/T and c.1298A/C genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene are associated with open angle glaucoma (OAG). METHODS Genomic DNA was examined in a cohort of 131 Japanese patients with normal tension glaucoma (NTG), 133 patients with primary open angle glaucoma (POAG), and 106 control subjects. The mean age at the time...

Purpose To examine the factors associated with blindness from primary open-angle glaucoma (POAG) among black and white patients at our institution. Patients and methods For this retrospective, case-control study, patients legally blind from POAG ("cases") were matched on age, race, and gender with non-blind POAG patients ("controls"). Thirty-seven black case-control pairs and 19 white case-co...

Background A patient decision aid (PDA) is a tool for shared decision making (SDM), which emphasises patient empowerment. It is useful in chronic diseases and when there are multiple, no best single treatment option. Although SDM is prevalent in Western countries, its use is limited in Chinese societies, where the adoption of a paternalistic approach is strong. Here, we report the development, ...