The mechanisms by which male sex hormones modulate cardiovascular function are a subject of contemporary interest. Several lines of evidence indicate that androgens can exert acute vasorelaxing effects. On the other hand, chronic exposure to androgens has been shown to promote increases in blood pressure and compromise renal function. In the present issue of Clinical Science, Malkin and co-work...

One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology. Here, we review our cur...

objective(s) the purpose of the present study was to evaluate the effect of ramadan fasting and weight-lifting training on plasma volume, glucose, and lipids profile of male weight-lifter. materials and methods forty male weight-lifters were recruited and divided into 4 groups (n=10 each) and as the following groups: control (c), fasting (f), training (t) and fasting-training (f-t). the t and f...

Reckelhoff, Jane F., Licy L. Yanes, Radu Iliescu, Lourdes A. Fortepiani, and Joey P. Granger. Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease. Am J Physiol Renal Physiol 289: F941–F948, 2005; 10.1152/ajprenal.00034.2005.—Treatment of aging men and women with testosterone supplements is increasing. The supplements are given to postmenopausal w...

Spotted hyenas (Crocuta crocuta) exhibit an array of behavioral and morphological characteristics that set them apart from other mammals: females are heavier and more aggressive than males, and females have external genitalia that closely resemble those of the male. Because androgenic hormones might mediate the expression of these traits, androgens are of great interest in this species. Past wo...

The relationships among testicular vein and jugular vein concentrations of androgens and estrogens were studied in anesthetized stallions. Blood was sampled from a vein on the surface of the testis and simultaneously from an artery on the surface of the testis and from the jugular vein. Concentrations of total 173hydroxy-androgens and total estrogens were measured for all samples and testostero...

Among all extant mammals, only the female spotted hyena (Crocuta crocuta) mates and gives birth through the tip of a peniform clitoris. Clitoral morphology is modulated by foetal exposure to endogenous, maternal androgens. First births through this organ are prolonged and remarkably difficult, often causing death in neonates. Additionally, mating poses a mechanical challenge for males, as they ...

Anti-androgens used in prostate cancer therapy inhibit AR (androgen receptor) activity via largely unknown mechanisms. Although initially successful in most cases, they eventually fail and the disease progresses. We need to elucidate how anti-androgens work to understand why they fail, and prolong their effects or design further therapies. Using a cellular model, we found different anti-androge...