atopic dermatitis (ad) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of t-helper 2 cells. the aim if this study was to determine whether cytokine gene polymorphisms might influence the development of ad. single nucleotide polymorphisms in the genes for i-l1alpha, il-1beta, il-1r, il-2, il-4, il-6, il-10, il-12, tgf beta, tnf and ifng...

background: management of multiple sclerosis (ms) is based on the usage of immunosuppressive and immune-modulating medications. cytokines play an important role in the pathogenesis of ms. objective: to evaluate the effects of rapamycin on the concentrations of th1/th2/th17 serum cytokines in patients with ms. methods: six patients with relapsing remitting ms as a case group and 6 healthy indivi...

interleukin-12 (il-12) is a key cytokine involved in regulating the balance between th1 and th2 cells by promoting th1 response. a reduced capacity to produce this cytokine could lead to aberrant th2 development. on the same aspect significant impact of il-12 on invariant natural killer t (inkt) cells was reported. therefore, we examined the serum levels of il-12 and the absolute number of peri...

Background: Patients with ulcerative colitis are at increased risk of inflammation. Interleukin 23 (IL-23) is a newly identified cytokine with increased expression in inflamed biopsies of colon mucosa in patients with Crohn's disease; however, there is inconsistent evidence on its role in ulcerative colitis. Objective: We aimed to compare serum IL-23 level in patients with ulcerative colitis an...

Résumé : La construction d’ontologies à partir de textes consiste à décrire des concepts par leurs relations conceptuelles et éventuellement leurs instances, à partir des matériaux textuels (termes, relations lexicales). Cet article propose une méthode pour mettre en lumière, par l’analyse de corpus, des relations lexicales susceptibles de donner naissance à des relations conceptuelles. Cette m...

This paper investigates the potential added-value of a combination of different kinds of linguistic information (i.e. information that belongs to morphological, syntactic and semantic levels of language). In particular, it aims at determining whether those various kinds of knowledge, when integrated within a single information retrieval system, have separately the same impact on its overall per...

Helicobacter pylori (H. pylori) infection has been reported in more than half of the world human population. It is associated with gastric inflammation and noticeable infiltration of the immune cells to the stomach mucosa by several cytokines secretion. IL-1&beta, IL-18 have been shown to contribute to H. pylori induced gastritis, but the details of inflammation and association of virulence fac...

patients with allergic rhinitis (ar) show increased production of the th2-related cytokines. almost always, intranasal corticosteroid (inc) and antihistamine are used as routine therapy of ar. this study was performed to determine the in vitro secretion of cytokines profiles of pbmcs in patients with ar sensitive to chenopodium album (ch.a) pollens before and after treatment with inc (fluticaso...