Caffeine modifies vascular/cardiac contractility. Embryonic exposure to caffeine altered cardiac functions in offspring. This study determined chronic influence of prenatal caffeine on vessel functions in offspring. Pregnant Sprague-Dawley rats (5-month-old) were exposed to high dose of caffeine, their offspring (5-month-old) were tested for vascular functions in mesenteric arteries (MA) and io...

The study investigated the effects of caffeine and ethanolic extract of kolanut (EEK) on glucose uptake in the canine hindlimb at rest and during contraction. Thirty male anaesthetized mongrel dogs [11-13 kg] were divided into six groups [5 dogs/group] Caffeine [6 mg/kg], EEK [5 mg/kg], or normal saline [control] was administered intravenously to each group at rest. Arterial and venous blood sa...

In this paper we investigate the effects of caffeine (5-20 mM) on ferret papillary muscle. The intracellular Ca2+ concentration ( [Ca2+]i) was measured from the light emitted by the photoprotein aequorin, which had previously been microinjected into superficial cells. Isometric tension was measured simultaneously. The rapid application of caffeine produced a transient increase of [Ca2+]i, which...

UNLABELLED The aims of this study were to investigate the anti-tumor effects of consecutive low-dose cisplatin (LD-CDDP) in comparison with single high-dose CDDP (HD-CDDP) in combination with caffeine. MATERIALS AND METHODS Human fibrosarcoma cells (HT-1080) were transplanted in BALB/C-nu mice. According to the administration of CDDP and caffeine, 5 groups were defined: HD-CDDP, LD-CDDP, HD-C...

[PDF] [Full Text] [Abstract] , August 1, 2004; 287 (2): F289-F298. Am J Physiol Renal Physiol S. Redling, I. L. Pfaff, M. Leitges and V. Vallon {varepsilon} in mouse kidney Immunolocalization of protein kinase C isoenzymes {alpha}, {beta}I, {beta}II, {delta}, and [PDF] [Full Text] [Abstract] , April 1, 2005; 313 (1): 403-409. J. Pharmacol. Exp. Ther. T. Rieg, H. Steigele, J. Schnermann, K. ...

OBJECTIVE To determine the effect of caffeine on diaphragmatic activity, tidal volume (Vt), and end-expiratory lung volume (EELV) in preterm infants. STUDY DESIGN Using transcutaneous electromyography of the diaphragm (dEMG), we measured diaphragmatic activity from 30 minutes before (baseline) to 3 hours after administration of an intravenous caffeine-base loading dose in 30 spontaneously bre...

The aim of this study was to investigate the influence ADORA2A and CYP1A2 genotypes on physiological ergogenic effects caffeine. Sixty-six male cyclists were screened for genotypes; with 40 taking part subsequently in a randomised, double-blind, placebo-controlled study. Trial 1 used establish oxygen uptake?power output relationship maximal uptake. In trials 2 3, participants ingested 5 mg·kg ?...

Caffeine is commonly prescribed in the NICU to treat apnea of prematurity. This review is an update based on current knowledge of the mechanisms of action, pharmacologic properties, clinical effects, and safety of caffeine in the neonatal population. Recent studies of caffeine in the neonatal population confirm its efficacy in treating apnea-related symptoms and reveal additional significant be...

The medial frontal cortex, especially the anterior cingulate cortex (ACC), is involved in action monitoring. We studied the role of moderate amounts of caffeine in action monitoring as expressed by the error-related negativity (ERN), an event-related brain component that reflects ACC activity. In a double-blind, placebo-controlled, within-subjects experiment, two caffeine doses (3 and 5 mg/kg b...

It was recently reported that caffeine may reduce the clinical symptoms of asthma and may prevent the clinical manifestations of this disease. The effect of caffeine on histamine responsiveness is unknown. The effect of caffeine (5 mg/kg) and placebo on histamine responsiveness (the provocation concentration causing a 20% fall in FEV1, PC20) was studied in 10 subjects with mild asthma (prechall...