background and aims: extended-spectrum β-lactamase (esbl) producing gram negative bacteria are resistant to penicillins, narrow and extended-spectrum cephalosporins, and aztreonam; also they are frequently resistant to trimethoprim-sulfamethoxazole, aminoglycosides, and quinolones. this study aimed to investigate the prevalence of plasmid-mediated quinolone resistance (pmqr) determinants qnra, ...

conclusions expression of armc3 in tumor samples and normal adjacent tissue is very important. the expression of this gene in tumor-adjacent tissue may be associated with the stage of cancer; it may be that these tissues are affected by epigenetic and oncogenic changes of breast cancer. accordingly, aberrant expression of armc3 in tumor samples may be an attractive candidate for use as a tumor ...

background: meiotic genes are very important candidates for genes contributing to female and male infertility. mammalian mutl homologues have dual roles in dna mismatch repair (mmr) after replication errors and meiotic reciprocal recombination. the mutl homologs, mlh1 and mlh3 , are crucial for meiotic reciprocal recombination and human fertility. in this study the functional polymorphisms of m...

Introduction: Previous studies revealed that oxidative stress is elevated in multiple sclerosis (MS). It can harm to biological macromolecules such as DNA. However, the molecular mechanism in protection of genetic information from DNA damages is not clear in MS disease. In this study the expression level of some important genes of OGG1 and MYH involved in base excision repair pathway and, MTH1 ...

Background: In fertile women, glycodelin and glutathione peroxidase 3 (GPx3) genes expression rises during the luteal phase, with a peak occurring during the implantation window. The expression of these genes decreases in women with myomas. To determine whether myomectomy would reverse glycodelin and GPx3 expression, we evaluated the transcript levels of these genes in the endometrium of patien...

Single-gene disorders occur when mutation in a gene causing alteration of gene function while in multifactorial disorders, mutations occur in multiple genes, and these are usually coupled with environmental causes. In addition, in a multifactorial disorder such as diabetes, the complication is under the influence of different genes. For example, in diabetic retinopathy many genes are involved i...

Background & objective: Microarray and next generation sequencing (NGS) data are the important sources to find helpful molecular patterns. Also, the great number of gene expression data increases the challenge of how to identify the biomarkers associated with cancer. The random forest (RF) is used to effectively analyze the problems of large-p and smal...

in order to determine resistance genetically potential of some bean genotypes to bean common mosaic virus, two separated experiments in randomized complete block design with 25 genotypes and three replications was conducted in iau shiraz branch. the first experiment and the second one were performed in normal and bcmv infected conditions, respectively. plants were inoculated in cotyledon leaf a...