The likelihood with which an action potential elicits neurotransmitter release, the release probability (p(r)), is an important component of synaptic strength. Regulatory mechanisms controlling several steps of synaptic vesicle (SV) exocytosis may affect p(r), yet their relative importance in determining p(r) and eliciting temporal changes in neurotransmitter release at individual synapses is l...

vidence that the cytokinetic apparatus is dependent on spindle microtubules comes primarily from classical experiments in which the spindle was manually moved or disrupted. On page 91, Bement et al. reveal the physiology that underlies these findings. Active RhoA localizes to a narrow zone at the site of future furrow formation in a microtubule-dependent manner, and the RhoA zone moves in respo...

Background: The appearance of multi-drug resistant microorganisms is becoming a global problem. Already several strategies have been employed to overcome antibiotic resistance issue. Developing new antimicrobial compounds from microbial sources could be a beneficial solution. Hence screening programs in order to discover new antibiotics from microbial entities are interesting. Because of high c...

T cells form intriguing patterns during adhesion to antigen-presenting cells. The patterns at the cell-cell contact zone are composed of two types of domains, which either contain short TCR/MHCp receptor-ligand complexes or the longer LFA-1/ICAM-1 complexes. The final pattern consists of a central TCR/MHCp domain surrounded by a ring-shaped LFA-1/ICAM-1 domain, while the characteristic pattern ...

two types of mineralization including porphyry copper and epithermal gold mineralization have occurred in relation with an intermediate volcano-plutonic complex in masjeddaghi area. different alterations including silica, advanced argillic, intermediate argillic and propylitic have been distinguished in relation with epithermal mineralization, which have a zonal pattern. elemental mass gains an...