Using an induced network module analysis of the deregulated genes in bulk transcriptome dataset murine IMQ model and human psoriasis, we have identified HIF-1α (Hypoxia-inducible factor 1 alpha) as a central hub that links numerous psoriasis signature (e.g. S100A8, S100A9, NOS2, VEGFA, RORC, SERPINB3, etc.). In addition, showed significant positive correlation with key psoriasis-associated clin...