Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Two supramolecular amphiphiles are fabricated through directional charge-transfer interactions, which self-assemble into nanofibers and nanoribbons. Due to the existence of galactose on their surface, these self-assemblies act as a cell glue to agglutinate E. coli, benefiting from multivalent interactions.

We prepared adamantane-containing amphiphiles and evaluated them using a large membrane protein complex in terms of protein solubilisation and stabilization efficacy. These agents were superior to conventional detergents, especially in terms of the membrane protein solubilisation efficiency, implying a new detergent structure-property relationship.

Polyoxometalates [SiM12O40](4-) (M = Mo(VI), W(VI)) and hemicyanine-derived chiral amphiphiles self-assemble in organic media where intermolecular interactions between POMs and hemicyanine units differ depending on the constituent metal ion species: this information is amplified to distinct spectral and self-assembling characteristics.

Gouveia, R. M., Castelletto, V., Alcock, S. G., Hamley, I. W. and Connon, C. J. (2013) Bioactive films produced from self­ assembling peptide amphiphiles as versatile substrates for tuning cell adhesion and tissue architecture in serum­free conditions. Journal of Materials Chemistry B, 1 (44). pp. 6157­ 6169. ISSN 0959­9428 doi: https://doi.org/10.1039/C3TB21031F Available at http://centaur.rea...

Synthetic amphiphiles have been found to self-assemble into a variety of structures such as micelles, vesicles, cylinders and lamellae in aqueous media over many length scales. We report herein cation-induced aggregation of hexaaza-cyclophanes in water. Pd(2+)- or proton-induced formation of submicro spherical aggregates was observed by several spectroscopic and microscopic methods.

Engineering nanostructures of defined size and morphology is a great challenge in the field of self-assembly. Herein we report on the formation of supramolecular nanostructures of defined morphologies with subtle structural changes for a new series of dendritic amphiphiles. Subsequently, we studied their application as nanocarriers for guest molecules.

We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.

New ionic amphiphiles with a hexyl-bridged bis(imidazolium) headgroup; Br(-), BF4(-), or Tf2N(-) anions; and a long n-alkyl tail can form thermotropic bicontinuous cubic liquid crystal phases in neat form and/or lyotropic bicontinuous cubic phases with several non-aqueous solvents or water.