The AMP-activated protein kinase cascade is activated by elevation of AMP and depression of ATP when cellular energy charge is compromised, leading to inhibition of anabolic pathways and activation of catabolic pathways. Here we show that the system responds in intact cells in an ultrasensitive manner over a critical range of nucleotide concentrations, in that only a 6-fold increase in activati...

The cellular mechanisms of AMP-Activated Protein Kinase (AMPK) activators in the treatment and prevention of diabetes, cancer, and cardiovascular disease.

The effects of epinephrine and insulin on three enzyme systems in adipocytes were investigated with regard to the role of adenosine 3’, 5’-monophosphate (cyclic AMP) in their control and the possibility that differential regulatory mechanisms might operate beyond cyclic AMP. When rat adipocytes were incubated with increasing concentrations of epinephrine (0.01 to 100 pM) elevation of cyclic AMP...

introduction: increased oxidative stress is widely accepted to be a factor in the development and progression of alzheimer’s disease. triazine derivatives possess a wide range of pharmacological activities including anti-oxidative and anti-in.ammatory actions. in this study, we aimed to investigate the possible protective effect of 3-thioethyl-5,6-dimethoxyphenyl-1,2,4-triazine (tedmt) on h2o2-...