IMPORTANCE Early, safe, effective, and durable evidence-based interventions for children and adolescents with chronic migraine do not exist. OBJECTIVE To determine the benefits of cognitive behavioral therapy (CBT) when combined with amitriptyline vs headache education plus amitriptyline. DESIGN, SETTING, AND PARTICIPANTS A randomized clinical trial of 135 youth (79% female) aged 10 to 17 y...

Plasmodia express a sphingomyelinase, which is apparently required for their development. On the other hand, the sphingomyelinase product ceramide has previously been shown to delay parasite development. Moreover, ceramide triggers suicidal erythrocyte death or eryptosis, characterized by exposure of phosphatidylserine at the erythrocyte surface and cell shrinkage. Accelerated eryptosis of infe...

OBJECTIVE To compare the efficacy and safety of duloxetine and amitriptyline in painful diabetic neuropathy (PDN). RESEARCH DESIGN AND METHODS In this randomized, double-blind, cross-over, active-control trial, 58 patients received amitriptyline and duloxetine orally once daily at bedtime, each for 6 weeks with optional dose uptitration fortnightly. Single-blinded placebo washout was given fo...

OBJECTIVE Studies indicate that serotoninergic and noradrenergic pathophysiological mechanisms may underlie both alcohol abuse/dependence and depressive disorder. The purpose of this study was to evaluate and compare the effectiveness and tolerability of two serotonergic and noradrenergic antidepressant drugs-mirtazapine and amitriptyline, for the treatment of patients with alcohol dependence c...

STUDY OBJECTIVES Rapid eye movement (REM) sleep is considered critical to the consolidation of procedural memory - the memory of skills and habits. Many antidepressants strongly suppress REM sleep, however, and procedural memory consolidation has been shown to be impaired in depressed patients on antidepressant therapy. As a result, it is important to determine whether antidepressive therapy ca...

A simple, accurate reverse phase high-performance liquid chromatographic method was developed and validated for the simultaneous estimation of Amitriptyline and Chlordiazepoxide in bulk and pharmaceutical dosage forms. Chromatography was carried out by using Chromosil C-18, column having 250 x 4.6mm internal diameter with a mixture of Methanol: Acetonitrile 70:30 (V/V) as mobile phase. Determin...

Relevance to family physicians Painful peripheral neuropathy is a common long-term complication of diabetes that affects about 45% of diabetics after 25 years of disease. The pain, which occurs in the hands and lower extremities, ranges from mild to severe and is usually described as a shooting, burning, or tingling sensation in the af fected area. The pain decreases patients’ quality of life a...

OBJECTIVE The aim of this study is to investigate the antidepressant and anxiolytic effects of simvastatin in rats. METHODS Sixty-four male adult (8-9 weeks old) Sprague-Dawley rats (200-250 g) were used. The forced swimming test and the elevated plus maze test were used for testing the antidepressant and anxiolytic effects. Eight groups were formed: control (saline), simvastatin 10, 30, and ...