1. We have examined the effects of aminophylline on the respiration and pulmonary circulation of eleven patients with chronic bronchitis and six patients with peripheral bronchial carcinoma; the latter were free from bronchial obstruction at the time of study. 2. Aminophylline caused an increase in total and alveolar ventilation and a decrease in arterial carbon dioxide tension. Lung diffusing ...

Adenosine and related compounds can produce atrioventricular (A-V) conduction block. Similar conduction disturbances are observed in myocardial hypoxia. To investigate the possibility that adenosine might be causally involved in hypoxic conduction disturbances, we measured A-V conduction times, subdivided into atrial-to-His bundle (A-H) and His bundle-to-ventricular (H-V) intervals, with extrac...

We have investigated the effects of adenosine on the cardiovascular system of the Antarctic fish Pagothenia borchgrevinki. Continuous measurements of ventral and dorsal aortic blood pressures, heart rate (fh) and ventral aortic blood flow (cardiac output, q_dot ) were made using standard cannulation techniques and a single-crystal Doppler flowmeter. On line measurements of arterial P(O2) were m...

Out of 62 asthmatic patients admitted to hospital with an acute exacerbation of their disease, those whose symptoms had not sufficiently improved 15 minutes after an initial intensive regimen were randomly allocated to receive an intravenous infusion of either salbutamol 10 microgram/min (20 patients) or aminophylline 1 mg/min (19 patients). During the infusions, which lasted 36 hours, peak exp...

CHEST, 70: 4, OCTOBER, 1976 if a 1-percent solution is adequate. We use 5 ml of a 4percent solution of lidocaine (for a total of 200 mg) to anesthetize the larynx and tracheobronchial tree. We have now performed over 4,500 examinations with the fiberoptic bronchoscope using the oral route of intubation and have encountered no episodes of serious laryngospasm.2 More importantly, we premedicate a...

BACKGROUND Theophylline has been widely used to treat asthma, but recent studies have revealed that the possible risks for seizure may result in the revision of the therapeutic guidelines. METHODS An 8-month-old boy who had been treated with oral sustained-release theophylline and additional aminophylline suppository was hospitalized. A combination of diazepam, lidocaine and thiopental was re...

YLLINE'(theophylline ethylenediamine) is one of the most useful drugs employed in the management of bronchial asthma . Its therapeutic effects are closely related to its blood level.' This should approximate from 5 to 9 mcg/ml in serum. Segal et al in 1949 demonstrated that a rectal solution of 0 .5 gm of aminophylline in 15 cc water yielded a significant degree of protection against histamine ...

Serum theophylline concentration was measured in children both during treatment of status asthmaticus with intravenous aminophylline, and as outpatients while they were taking oral theophylline compounds for long-term management of asthma. The clinical value of the measurements was assessed. Measurement using high-pressure liquid chromatography is simple and requires only a small volume of bloo...

Ethylenediamine tetraacetate (EDTA)-mediated calcite dissolution occurs via a different process than water-promoted dissolution. Near-atomic-scale observations in EDTA solutions demonstrate that, after penetration through a critical pit depth barrier, step velocity increases linearly with pit depth for EDTA-promoted dissolution. The parallel processes of water-dominated dissolution at point def...