Protein malnutrition occurs when there is insufficient protein to meet metabolic demands. Previous works have indicated that cycles of protein fasting/refeeding enhance the incidence of early lesions during chemical carcinogenesis in rat liver. The general objective of this work was to study the effect of aminoacids (Aa) deprivation on the proliferation and survival of hepatocytes, to understan...

In the earlier article I introduced the notion of Hamiltonian cycle as a mathematical model for musical harmony and also proposed a connection with biology: motivations came from two observations. The number of icosahedral vertices is 12 and corresponds to the number of notes in 12-note system and the number of triangular faces of icosahedron is 20, the number of aminoacids. This led to a group...

Amino acids are well known to be an important class of compounds for the maintenance of body homeostasis and their deficit, even for the polar neuroactive aminoacids, can be controlled by supplementation. However, for the amino acid taurine (2-aminoethanesulfonic acid) this is not true. Due its special physicochemical properties, taurine is unable to cross the blood-brain barrier. In addition o...

Introduction: In respect to other molecular imaging modalities the low sensitivity is the main limitation of the MagneticResonance-Molecular-Imaging approach. Therefore, the success of a MR-Molecular Imaging protocol strongly relies on the amplification effects associated to the accumulation of the agents at the cells of interest. Efficient routes to accumulate imaging probes in tumor cells may...

Typical migraine headaches have been consistently induced by the administration of reserpine to migrainous patients. In such patients an increase in urinary excretion of histidine and lysine has been reported to accompany attacks of migraine (Kimball and Friedman, 1961; Menkes, 1964). These aminoacids have also been found in the oedema fluid which accumulates near the temporal arteries of patie...

We show that carbonaceous chondrite meteorites actively and selectively catalyze the formation of relevant prebiotic molecules from formamide in aqueous media. Specific catalytic behaviours are observed, depending on the origin and composition of the chondrites and on the type of water present in the system (activity: thermal > seawater > pure). We report the one-pot synthesis of all the natura...

Microdialysis is a technique that was devised by Bito et al. (1966) in a study to determine free aminoacids and electrolytes in cerebrospinal fluid and blood plasma in dogs. It consists of recollection of samples in specific places by using semi-permeable membranes, used to evaluate compounds (endogenous neurotransmitters or exogenous such as drugs), in extracellular spaces from different tissu...

In a s t r a i n of K. l a c t i s . the RAG 2 gene (1) i s found as a recessive a l l e l i c form, rap2. The s t ra in cannot grow on glucose if the respi ra tory pathway i s blocked by mitochondrial i n h i b i t o r s . The RAG2 gene has been cloned and i t s nucleot ide sequence determined. The 557 aminoacids long open reading frame has a homology of 56,5% with mouse neuroleukine (2) which...

Cleistanthus collinus, a toxic plant, contains three glycosidic compounds, Cleistanthin A, B and C. Cultured K562 cells were treated with 1μg/ml and 10μg/ ml of each Cleistanthins (A and B). At higher concentration a significant dose dependent decrease has been noted in the incorporation of thymidine and uridine into DNA and RNA, respectively. However, no significant difference in leucine incor...

The preliminary phytochemical study and invitro antimicrobial activity of Coriander sativum (Apiaceae) was investigated against some pathogens isolated from patients with infectious diarrhea. The various solvents extract like aqueous, methanol, chloroform, petroleum ether and hexane were screened for antimicrobial activity against Enterotoxigenic E.coli, Enteropathogenic E.coli,, Salmonella typ...