some amide derivatives have been synthesized by the reaction of corresponding nitriles with potassium tert-butoxide as a nucleophilic oxygen source under ultrasonic irradiation. this new methodology provides good to excellent yields in short reaction times (15-90 min) at room temperature.

The [3+2] cycloaddition between various nitriles and sodium azide proceeds smoothly in the presence of zeolite and sulfated Zircona as effective catalyst and in the water and DMF/MeOH, to give the corresponding arylaminotetrazoles in good to high yields. The reaction most probably precedes through the in situ formation of a catalyst azide species, followed by a successive [3+2] cycloaddition wi...

5-Substituted-1H-tetrazoles were synthesized by the [3 + 2] cycloaddition of sodium azide with various nitriles in the presence of nickel zirconium phosphate (NiZrP) as an effective heterogeneous catalyst in dimethylsulfoxide at 120 °C. This method has the advantages of good to high yields, simple methodology and easy work-up. The catalyst can be recovered by centrifuging and reused with good y...

The synthesis of 2-substituted benzothiazoles has been described using ZnO-nanoparticles as a catalyst. condensation 2-aminothiophenol and aryl/alkyl nitriles resulted in the formation va...

The first method for the stereoconvergent cross-coupling of racemic α-halonitriles is described, specifically, nickel-catalyzed Negishi arylations and alkenylations that furnish an array of enantioenriched α-arylnitriles and allylic nitriles, respectively. Noteworthy features of this investigation include: the highly enantioselective synthesis of α-alkyl-α-aryl nitriles that bear secondary α-al...

Nitrile is a functional group that usually is transformed to amides or carboxylic acids under strong reaction conditions in acidic or basic media and high temperatures. Amides have also been prepared from nitriles at room temperature using strong oxidizing agents such as hydrogen peroxide or sodium superoxide in DMSO. On the other hand biocatalytic hydrolysis of nitriles mediated by nitrilase, ...

Methyl azelaaldehydate, soy nitriles, and oleonitrile were compared as starting materials for making nylon-9. Less difficulty was encountered in purifying intermediates from oleonitrile than from the other two. All 3 routes involved hydrolysis of methyl 9-aminononanoate to 9-aminononanoic acid. Self catalyzed hydrolysis of the amino ester in water produced low yields of monomer owing to oligome...

From orbit, the visibility of Titan's surface is limited to a handful narrow spectral windows in near-infrared (near-IR), primarily from absorption methane gas. This has ability identify specific compounds on -- date bulk composition remains unknown. Further, understanding would provide insight into geologic processes, photochemical production and evolution, biological potential surface. One ap...

Two series of extremely useful 2-C-substituted benzothiazoles containing gem-bisphosphonates and aryl-substituted nitriles were synthesized here via a copper-promoted domino condensation/S-arylation/heterocyclization process.

Various N-heteroaromatic compounds, including pyridines, quinolines and isoquinoline, react with arynes and nitrile-containing solvents to give N-arylated 1,2-dihydro-2-pyridinyl, -2-quinolinyl and -1-isoquinolinyl nitriles in excellent yields.