نتایج جستجو برای: amino acid substitution
تعداد نتایج: 860559 فیلتر نتایج به سال:
Single and dual amino acid substitution variants were generated in the TCR CDRs of three TCRs that recognize tumor-associated Ags. Substitutions that enhance the reactivity of TCR gene-modified T cells to the cognate Ag complex were identified using a rapid RNA-based transfection system. The screening of a panel of variants of the 1G4 TCR, that recognizes a peptide corresponding to amino acid r...
The genomic era has seen a remarkable increase in the number of genomes being sequenced and annotated. Nonetheless, annotation remains a serious challenge for compositionally biased genomes. For the preliminary annotation, popular nucleotide and protein comparison methods such as BLAST are widely employed. These methods make use of matrices to score alignments such as the amino acid substitutio...
A procedure to map score matrices in n-dimensional spaces is presented. Score or substitutions matrices are used as similarity-like measure between amino acid in protein alignment procedures. The first stage of heuristic local alignments procedures as FASTA and BLAST uses local matching of very short sequences, also named k-tuples. By using L1 metric this matching task can be computed very fast...
2 THE DISCRIMINATIVE MODEL SPACE CONTAINS THE GENERATIVE MODEL SPACE In the following we will show that the generative model with any set of parameters is equivalent to the discriminative model with an appropriately chosen set of parameters. In other words, the discriminative model with these particular parameters predicts the same context-specific substitution probabilities P (a|Ci) as the gen...
Motivation: We address the question of whether there exists an effective evolutionary model of amino-acid substitution that forms a metric-distance function. There is always a trade-off between speed and sensitivity among competing computational methods of determining sequence homology. A metric model of evolution is a prerequisite for the development of an entire class of fast sequence analysi...
We present a formal analysis of amino acid replacement during mRNA translation. Building on an abstract stochastic model of arrival of tRNAs and their processing at the ribosome, we compute probabilities of the insertion of amino acids into the nascent polypeptide chain. To this end, we integrate the probabilistic model checker Prism in the Matlab environment. We construct the substitution matr...
BACKGROUND The effect of single and multiple amino acid substitutions in the green fluorescent protein (GFP) from Aequorea victoria has been extensively explored, yielding several proteins of diverse spectral properties. However, the role of amino acid deletions in this protein -as with most proteins- is still unknown, due to the technical difficulties involved in generating combinatorial in-ph...
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