Entamoeba histolytica (Eh) is the causative agent of amebiasis, one of the major causes of dysentery-related morbidity worldwide. Recent studies have underlined the importance of the intercellular junction between Eh and host cells as a determinant in the pathogenesis of amebiasis. Despite the fact that direct contact and ligation between Eh surface Gal-lectin and EhCP-A5 with macrophage α5β1 i...

Entamoeba histolytica (Eh) is an extracellular protozoan parasite of humans that invades the colon to cause life-threatening intestinal and extra-intestinal amebiasis. Colonized Eh is asymptomatic, however, when trophozoites adhere to host cells there is a considerable inflammatory response that is critical in the pathogenesis of amebiasis. The host and/or parasite factors that trigger the infl...

BACKGROUND Transmission of Entamoeba histolytica generally occurs by fecal excretion of cysts followed by oral ingestion of contaminated food or water. However, fecal-oral transmission may occur within households and long-term care institutions, and sexual transmission occurs among men who have sex with men. Epidemiologically linked clusters of E. histolytica infection are rare in industrialize...

The application of molecular biologic techniques over the past decade has seen a tremendous growth in our knowledge of the biology of Entamoeba histolytica, the causative agent of amebic dysentery and amebic liver abscess. This approach has also led to the identification and structural characterization of three amebic antigens, the serine-rich Entamoeba histolytica protein (SREHP), the 170-kDa ...

We have previously shown that vaccination with purified Entamoeba histolytica Gal/GalNAc lectin or recombinant subunits can protect mice from intestinal amebiasis upon intracecal challenge. In this study, we demonstrated with adoptive-transfer experiments that this lectin vaccine protection is mediated by T cells but not serum. The cell-mediated immune (CMI) response was characterized by signif...

background: we examined a molecular method with a single-pcr for amplification of a part of cp5 gene enabling us to differen­tiate the pathogenic species, entamoeba histolytica , from the non-pathogenic species, e. dispar . methods: we developed a single pcr method for this purpose.  after investigation of genbank, primer pairs were de­signed from highly conserved regions of cysteine proteinase...

The protozoan parasite Entamoeba histolytica is responsible for invasive intestinal and extraintestinal amebiasis. The virulence of Entamoeba histolytica is strongly correlated with the parasite's capacity to effectively kill and phagocytose host cells. The process by which host cells are killed and phagocytosed follows a sequential model of adherence, cell killing, initiation of phagocytosis, ...

1 Cook GC. Tropicalgastroenterology. Oxford: Oxford University Press, 1980:373,381,394. 2 Ambroise-Thomas P. Amebiasis and other protozoal diseases. In: Houba V, ed. Immunological investigation oftropical parasitic diseases. Edinburgh, London, New York: Churchill Livingstone, 1980:75-83. 3 Smith PD. Infectious agents and inflammatory bowel disease. Gastroenterologc 1983;85:475-6. 4 Gorbach SL. ...

Dear Editor, Entamoeba histolytica, the causative agent of intestinal amoebiasis affects more than 50 million people worldwide. Amoebiasis is considered to be the most common parasitic infection particularly in the tropics and subtropics.[1] It is the second leading cause of the death from parasitic diseases worldwide.[2] Humans are the primary reservoir and infection happens to be by ingestion...

Amoebiasis is a problem in northern India. In Ayurveda several herbal drugs are mentioned, to be used for controlling the amatisara (amoebiasis) but none of the drug are found having potent effect to iradicate the disease. In ancient literature kutaj (Holarrhena antidysentrica) is mentioned in commonest was for controlling the disease this plant is prevalently found in Himalayan and vindhaya ar...