BACKGROUND Allograft vasculopathy is a major limiting factor in the long-term success of cardiac transplantation. T cells play a critical role in initiation of cardiac allograft rejection and allograft vasculopathy. The negative T-cell costimulatory pathway PD-1:PDL1/PDL2 (programmed death-1:programmed death ligand-1/2) plays an important role in regulating alloimmune responses. We investigated...

STUDY DESIGN Systematic review. OBJECTIVE To compare the effectiveness and safety between iliac crest bone graft (ICBG), non-ICBG autologous bone, and allograft in cervical spine fusion. To avoid problems at the donor site, various allograft materials have been used as a substitute for autograft. However, there are still questions as to the comparative effectiveness and safety of cadaver allo...

Abstract Introduction: Fractures in osteoporotic bones present a surgical challenge for fixation and are often associated with significant morbidity. Case presentation: We case of failed internal fracture femoral shaft 74-year-old patient osteoporosis. Fracture was undertaken using an extra medullary locking plate intramedullary cortical strut graft, hybrid technique, Locking Plate Allograft Co...

Donor-specific HLA antibodies are responsible for most early renal allograft rejections and allograft losses. Therefore, detection of HLA antibodies prior to transplantation is an important step in the evaluation of renal allograft recipients. In this mini-review we will describe recent advances in the techniques used to detect donor-specific HLA antibodies with emphasis on their potential appl...

BACKGROUND The biological recovery of human skin allografts is the gold standard for preservation in Skin Banks. However, there is no worldwide consensus about specific allocation criteria for preserved human skin allografts with living cells. A report is presented on the results of 5 years of experience of using human skin allografts in burned patient in the Skin and Tissue Bank at the "Instit...

The effect of recipient hepatitis C virus (HCV) infection on renal allograft loss and acute rejection in kidney transplantation remains controversial. We studied 354 renal allograft recipients transplanted during 1996 to 2001 who had HCV antibodies (Ab) measured before transplantation. The primary outcome was death-censored allograft loss and the secondary outcome was acute humoral rejection (A...

Allograft and autograft tissues have proven to be invaluable treatment modalities for patients with a variety of injuries, from athletes with musculoskeletal sports injuries to victims of severe burns to those requiring solid organ transplantation. Skin grafting is a viable treatment in the care of large burns, and the use of allografts in organ transplantation is great in breadth—allograft car...

A 29-year-old man developed chronic allograft nephropathy 63 months after renal transplantation. He became symptomatic with advanced chronic graft failure; his immunosuppressive medications were reduced and he was commenced on haemodialysis. Two months following the withdrawal of immunosuppression, he presented with abdominal pain, haematuria, and a marked drop in haemoglobin. The patient was t...

The major findings regarding corneal allograft rejection in experimental animals are reviewed. The principal anatomic and biological feature of the cornea that determines the immunologic privilege of this tissue is its avascularity. The surgical trauma of transplantation compromises the immunologic privilege, putting corneal allografts at risk for immune rejection. During the past 50 yr, rabbit...

Introduction: Slipped capital femoral epiphysis (SCFE) is the most common hip disorder affecting adolescent children [1]. The etiology is thought to be multifactorial, related to both biological and biomechanical factors [2]. SCFE occurs when the epiphysis of the proximal femur slips in relation to the metaphysis through the growth plate, causing pain, disability and potential long-term sequell...