Tuberculosis is one of the major public health problems faced globally. Resistance of Mycobacterium tuberculosis to antitubercular agents has called for an urgent need to investigate newer drugs to combat tuberculosis. Garlic (Allium sativum) is an edible plant which has generated a lot of curiosity throughout human history as a medicinal plant. Garlic contains sulfur compounds like allicin, aj...

When garlic cloves are chopped or crushed several dialkyl thiosulfinates are rapidly formed by the action of the enzyme alliin lyase or alliinase (EC 4.4.1.4) on S(+)-alkyl-L-cysteine sulfoxides. Allicin (diallyl thiosulfinate or allyl 2-propene thiosulfinate) is the dominant thiosulfinate released. A variety of sulfur containing compounds are formed from allicin and other thiosulfinates depend...

(1) Facultad de Ciencias Agrarias y Forestales, Universidad Nacional de La Plata. CIDEFI (Centro de Investigaciones de Fitopatología)-CONICET Dirección: 60 y 119 (1900) La Plata, Provincia de Buenos Aires, Argentina E-mail: [email protected] Lugar de trabajo del proyecto: RWTH Institut für Pflanzenphysiologie, Lab. Biologie III, Worringerweg 1 (52074) Aachen, supported by Alexander von H...

sativum L.) is now believed due to the properties of its active principle, allyithiosuffinicallyl ester, allicin (6). Allicin is produced by enzymatic degra dation of alum, S-allyl-frcysteine-S-oxide. Inhibi tion of sulfhydryl enzymes is associated with the presence of the —SO—S—grouping(11). The role of suffhydryl groups in cell division and mitoses has been reviewed by Barron (1) : an i...

phytochemical constituents, such as total phenol, allicin and pyrovic acid as well as antioxidant activity of thirteen ecotypes of allium hirtifolium boiss. from different regions of iran were evaluated. average contents of total phenol, allicin and pyrovic acid of bulbs extracts per g fresh weight were 0.647 mg gallic acid equivalent (gae), 2.127 mg and 84.412 µmol, respectively and antioxidan...