The Tien Shan are the quintessential intracontinental range, situated more than 1000 km north of the suture between India and Asia. Their initiation and growth in the Cenozoic, however, remain poorly understood. In this study we present stratigraphic, detrital fission-track, and magnetostratigraphic results that provide a basis for reconstructing the Cenozoic tectonic evolution of the Kyrgyz Ra...

We studied the effect of extremely low frequency (ELF) currents on gap junction intercellular communication (GJIC) mediated by connexin43 protein. Confluent monolayers of synovial fibroblasts (HIG-82) and neuroblastoma cells (5Y) were exposed in bath solution to 0-75 mA/m(2) (0-56 mV/m), 60 Hz. Single channel conductance, cell membrane current-voltage (I-V) curves, and Ca(2+) influx were measur...

* Asterisk denotes corresponding author. Affiliations: 1 Systems Analysis, Modelling and Prediction (SAMP), Department of Engineering Science, University of Oxford, Oxford, UK 2 Oxford Centre for Industrial and Applied Mathematics (OCIAM), University of Oxford, Oxford, UK 3 Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA 4 Smith School of Enterprise and the Environment, Uni...

1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 2 Northern California Cancer Center, Fremont, CA. 3 Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA. 4 Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark. 5 Department of Pathology, Akad...

Zircon grains from metasiltstone beds in the Precambrian Ashburn Formation were dated to constrain age of stromatolite Archaeozoon acadiense. The largest group analyzed consists mostly well-rounded detrital zircon no younger than 1060 Ma with significant peaks at about 1200–1100, 1500, 1800, 2050, and 2700 Ma, as well a few Mesoarchean ages. A second population apparently euhedral gives ages ra...

BACKGROUND Homozygous or double heterozygous factor XIII (FXIII) deficiency is characterized by soft tissue hematomas, intracranial and delayed spontaneous bleeding. Alterations of thromboelastography (TEG) parameters in these patients have been reported. The aim of the study was to show results of TEG, TEG Lysis (Lys 60) induced by subthreshold concentrations of streptokinase (SK), and to comp...

Insulin is secreted from the -cells of the pancreatic islets by Ca 2 -dependent exocytosis of large dense core vesicles (LDCVs) (Ämmälä et al., 1993), a process that is triggered by glucose-induced electrical activity (Henquin and Meissner, 1984). In response to a step elevation of glucose, insulin secretion follows a characteristic biphasic time course (Curry et al., 1968): an initial transien...

Brown, Angus M., and Bruce R. Ransom. Neuroprotective effects of increased extracellular Ca during aglycemia in white matter. J Neurophysiol 88: 1302–1307, 2002; 10.1152/jn.00113.2002. We investigated the effects of extracellular [Ca ] ([Ca ]o) on aglycemiainduced dysfunction and injury in adult rat optic nerves. Compound action potentials (CAPs) from adult rat optic nerve were recorded in vitr...

Mice expressing the human Cu /Zn superoxide dismutase 1 (hSOD1) gene mutation (hSOD1; G93A) were exposed to methylmercury (MeHg) at concentrations that did not cause overt motor dysfunction. We hypothesized that low concentrations of MeHg could hasten development of the amyotrophic lateral sclerosis (ALS)-like phenotype in G93A mice. MeHg (1 or 3 ppm/day in drinking water) concentration-depende...

M. K. Y. Chan,1,2 J. Reed,3 D. Donadio,4 T. Mueller,2 Y. S. Meng,2,5 G. Galli,4 and G. Ceder2 1Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 2Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3Lawrence Livermore National Laboratory, Livermore, CA 94551, USA 4Department of Chemistry, Universit...